ArticleAsian Pacific journal of cancer prevention : APJCP2025
The Effect of Moringa Oleifera Ethanol Extract on Improving Cisplatin Induced Liver Cells Damages.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCisplatin, a widely used therapy for solid tumors, is associated with hepatotoxicity characterized by cytoplasmic vacuolization of liver cells, sinusoidal congestion, mononuclear and Kupffer cell infiltration, and focal necrosis. Moringa oleifera (M. oleifera) leaves, rich in flavonoids with antioxidant properties, may mitigate hepatotoxicity. This study aimed to evaluate the effects of ethanol extract of M. oleifera leaves on inflammation, oxidative stress, and liver cell damage in a rat model of cisplatin-induced hepatotoxicity.
methodsThirty male Sprague-Dawley rats were divided into 11 groups, including controls and treatment cohorts. Cisplatin (5 mg/kgBW) was administered as a single dose, followed by a 28-day observation. M. oleifera was administered daily at doses of 300, 600, and 1200 mg/kgBW using three regimens: pre-treatment (7 days prior to cisplatin), concurrent treatment (simultaneously with cisplatin), and post-treatment (7 days after cisplatin). On day 28, blood samples were analyzed for alanine aminotransferase (ALT), malondialdehyde (MDA), and nuclear factor kappa beta (NF-κβ), while liver tissues were assessed for cysteine-aspartic proteases (caspase)-3 levels and histopathological changes.
resultsPre-treatment with M. oleifera demonstrated the most effective reduction in liver damage, with the 1,200 mg/kgBW dose yielding optimal protective effects across all parameters. Significant differences (p < 0.05) were observed in all measured variables across the treatment groups and dosing regimens.
conclusionM. oleifera exhibits a dose-dependent ability to mitigate inflammation, oxidative stress, and liver cell damage caused by cisplatin. The pre-treatment regimen with M. oleifera was the most effective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.