Evidence map›Paper›PMID 40542769›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

The Anticancer Effect of Haematococcus Pluvialis Alga Extract on Breast Cancer Cell Line.

Vahideh Shamskhani, Habib Zarredar, Jafar Razeghi, Atefeh Ansarin, Milad Asadi, Zahra Soleimani, Ensiyeh Seyedrezazadeh

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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vahideh ShamskhaniDepartment of Plant Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Habib ZarredarTuberculosis and Lung Diseases Research Canter, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID 0000-0002-7217-7521
Jafar RazeghiDepartment of Plant Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Atefeh AnsarinTuberculosis and Lung Diseases Research Canter, Tabriz University of Medical Sciences, Tabriz, Iran.
Milad AsadiDepartment of Basic Oncology, Ege University, Institute of Health Sciences, Izmir, Turkey.ORCID 0000-0001-7846-2908
Zahra SoleimaniRahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ensiyeh SeyedrezazadehTuberculosis and Lung Diseases Research Canter, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate the anticancer effects of H. pluvialis extract on breast cancer.  Methods: We evaluated the cytotoxicity, suppression of migration, and apoptosis ability of H. pluvialis alga extract MDA-MB-468 by MTT assay, scratch test, and flow cytometry, respectively. The expression patterns of MMP1 and MMP9, Bax and Bcl2, Caspase3, Caspase6, and Caspase9 were analyzed by qRT-PCR.

resultsBased on the findings of this study, the survival and proliferation capacity of MDA-MB-468 cells treated with the extract was reduced. Flow cytometry results showed that treatment with H. Pluvialis extracts induced apoptosis. Scratch test results showed that H. Pluvialis extract could inhibit cell migration. The expression patterns of the studied genes were changed by treatment with the extract. Expression of Bcl2, MMP1, and MMP9 genes decreased, and expression of Bax, Caspase3, Caspase8, Caspase9 genes increased.

conclusionThe findings of this research reveal that H. pluvialis algae extract shows a potential anti-cancer compound.

Indexed as

ApoptosisBreast NeoplasmsChlorophytaPlant ExtractsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansTumor Cells, CulturedPlant ExtractsApoptosisbreast cancerCell migrationHaematococcus Pluvialis

Identifiers

PMID40542769
PMCPMC12374507

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.