Evidence map›Paper›PMID 40542722›Full record

ArticleJournal of medicinal chemistry2025

Design of a Fluorescence Polarization Probe for Enterovirus 2C Proteins.

Kan Li, Hiwot A Demssie, Jun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kan LiDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Hiwot A DemssieDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Jun WangDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-4845-4621

Funding

Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antiviralsR01AI158775 · NIAID · UNIVERSITY OF ARIZONA · PI Jun Wang · 2021 to 2026
$3.6M
Drug target validation of the enterovirus D68 2A proteaseR01AI157046 · NIAID · UNIVERSITY OF ARIZONA · PI WANG, JUN · 2020 to 2024
$3.4M
Development of 2C inhibitors as broad-spectrum enterovirus antiviralsR01AI179926 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Jun Wang · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI157046NIAID NIH HHS R01 AI158775NIAID NIH HHS R01 AI179926
6 · The paper itself

Abstract

Enteroviruses (EVs), such as EV-D68, EV-A71, and CVB3, cause significant human disease; yet, no antivirals are currently approved. The highly conserved 2C protein, an essential AAA+ ATPase and helicase, is a prime antiviral target; however, it lacks suitable assays for inhibitor screening. Here, we report a fluorescence polarization (FP) assay using a rationally designed probe,

Indexed as

Antiviral AgentsDrug DesignEnterovirusFluorescence PolarizationFluorescent DyesViral Nonstructural ProteinsCarrier ProteinsHumansStructure-Activity Relationship2C protein, viralAntiviral AgentsCarrier ProteinsFluorescent DyesViral Nonstructural Proteins

Identifiers

PMID40542722
PMCPMC12333363

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.