ArticleEpigenomics2025
Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C.
Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Fascination with RNA Editing: In the Lights of Evolution and Biology.Journal of molecular evolution · 2025Review
- On the origin, evolution, and maintenance of RNA editing.Nucleic acids research · 2025Review
- Promiscuous RNA editing in lncRNARNA (New York, N.Y.) · 2025Article
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Authors and funding
1 author.
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Abstract
Adenosine-to-inosine (A-to-I) mRNA editing epigenetically mimics A-to-G mutations. While literatures usually state "inosines are recognized as guanosines," sometimes we also see expressions like "inosines basepair with cytosines." In this article, I stress that the two expressions are not equivalent at all for the following reasons. (1) inosines are recognized as guanosines only when located in mRNAs, not tRNAs; (2) even when being recognized as guanosines, inosines can basepair with cytosine and uracil; (3) when inosine pairs with cytosine, the basepairing efficiency differs from G:C pairing. Therefore, we should be cautious when introducing A-to-I RNA editing. "inosines basepair with cytosines" is an inaccurate or incomplete interpretation and should be corrected as "inosines in mRNAs are recognized as guanosines."
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