Evidence map›Paper›PMID 40542610›Full record

ArticleJournal of cellular and molecular medicine2025

Protective Effects of COG133 on Carbon Tetrachloride-Induced Acute Liver Injury: Modulation of Inflammation, Apoptosis and Sphingolipid Metabolism.

Mutay Aslan, Bürke Çırçırlı, Aleyna Öztüzün, Hazal Tuzcu, Çağatay Yılmaz, Tuğçe Çeker, Gülsüm Özlem Elpek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mutay AslanDepartment of Medical Biochemistry, Akdeniz University Faculty of Medicine, Antalya, Turkey.ORCID 0000-0002-0660-971X
Bürke ÇırçırlıDepartment of Medical Biotechnology, Institute of Health Sciences, Akdeniz University, Antalya, Turkey.
Aleyna ÖztüzünDepartment of Medical Biochemistry, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Hazal TuzcuDepartment of Pathology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Çağatay YılmazDepartment of Medical Biochemistry, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Tuğçe ÇekerDepartment of Medical Biochemistry, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Gülsüm Özlem ElpekDepartment of Pathology, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Funding

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 123S697
6 · The paper itself

Abstract

Acute liver hepatotoxicity, characterised by inflammation, apoptosis and metabolic dysfunction, is often caused by drug-induced toxic events. This study evaluated the protective effects of COG133, a synthetic peptide derived from apolipoprotein E (ApoE), against carbon tetrachloride (CCl

Indexed as

ApoptosisChemical and Drug Induced Liver InjuryInflammationPeptidesProtective AgentsSphingolipidsAnimalsCarbon TetrachlorideCell LineCell SurvivalHepatic Stellate CellsHepatocytesLiverMaleOxidative StressRatsCarbon TetrachloridePeptidesProtective AgentsSphingolipidsacute hepatotoxicityapoptosiscarbon tetrachlorideCOG133inflammationsphingolipids

Identifiers

PMID40542610
PMCPMC12181747

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.