ArticleThoracic cancer2025
Late-Onset Crizotinib-Associated Renal Cysts With Subsequent Regression Following Dose Reduction: A Case Report.
Article in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Case Report: Reconstruction of the chest wall with titanium alloy plates after resection of a rare malignant spindle cell tumor of the sternum complicated by ankylosing spondylitis.Frontiers in surgery · 2026Article
- Aseptic inflammatory abscesses induced by crizotinib in a case report of ALK rearrangement lung adenocarcinoma.Frontiers in oncology · 2026Article
- Late-Onset Crizotinib-Associated Renal Cysts With Subsequent Regression Following Dose Reduction: A Case Report.Thoracic cancer · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crizotinib, an anaplastic lymphoma kinase (ALK)/ROS1/c-MET inhibitor, improves outcomes in ALK-positive non-small cell lung cancer (NSCLC) but can cause crizotinib-associated renal cysts (CARCs), a rare yet clinically relevant adverse effect. We report a case of a 68-year-old Korean male who developed complex renal cysts after 4 years of crizotinib therapy. Radiologic findings initially raised suspicion for either an abscess or a neoplastic lesion, leading to surgical resection. However, recurrent renal cysts developed during continued crizotinib therapy, and CARCs were subsequently suspected. A dose reduction was implemented, which led to cyst regression without compromising tumor control. This case highlights the need to recognize and manage late-onset toxicities during long-term treatment, emphasizing the clinical value of multidisciplinary evaluation and tailored dose adjustments.
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