Evidence map›Paper›PMID 40542473›Full record

ArticleJournal of agricultural and food chemistry2025

Efficient Production of Shinorine and Mycosporine-Glycine-Alanine in

Daeyeol Lee, Hyunbin Jin, Sojeong Kim, Sunwoo Kim, Eunyoung Park, Dongwon Yoo, Ji-Sook Hahn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daeyeol LeeDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Hyunbin JinDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Sojeong KimDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Sunwoo KimDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Eunyoung ParkDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Dongwon YooDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-4547-6948
Ji-Sook HahnDepartment of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-3710-3674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycosporine-like amino acids (MAAs) are ultraviolet-absorbing metabolites with recognized photoprotective and pharmacological benefits, predominantly found in marine organisms. Due to the inefficiency of extraction from natural sources, microbial biosynthesis using heterologous hosts is an attractive alternative. Disubstituted MAAs, such as shinorine, porphyra-334, and mycosporine-2-glycine, are synthesized by conjugating serine, threonine, or glycine to mycosporine-glycine (MG), a reaction catalyzed by either a d-Ala-d-Ala ligase homolog (MysD) or a nonribosomal peptide synthetase (MysE). While MysD enzymes often yield diverse byproducts due to substrate promiscuity, MysE demonstrates higher substrate specificity; however, only a serine-specific MysE has been biochemically characterized. In this study, we enhanced shinorine production in

Indexed as

Bacterial ProteinsCyclohexanolsCyclohexanonesCyclohexylaminesFungal ProteinsGlycinePeptide SynthasesPiperidonesYarrowiaMetabolic EngineeringBacterial ProteinsCyclohexanolsCyclohexanonesCyclohexylaminesFungal ProteinsGlycinemycosporine-2-glycinenon-ribosomal peptide synthasePeptide SynthasesPiperidonesshinorinemycosporine-glycine-alanineMysEnonribosomal peptide synthetase (NRPS)phosphopantetheinyl transferase (PPTase)shinorineYarrowia lipolytica

Identifiers

PMID40542473
PMCPMC12232313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.