Evidence map›Paper›PMID 40542447›Full record

ArticleNeurological research and practice2025

Observational quality control study: insourcing multi-PCR-impact on the use of anti-infectives for patients with pleocytosis.

Jörg Tebben, Bianca Wiebalck, Holger Schmidt

Abstract read
In one paragraph

Article in Neurological research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jörg TebbenNeurologie, Elbe Kliniken, Bremervörder Strasse 111, 21682, Stade, Lower Saxony, Germany.
Bianca WiebalckNeurologie, Elbe Kliniken, Bremervörder Strasse 111, 21682, Stade, Lower Saxony, Germany.
Holger SchmidtNeurologie, Elbe Kliniken, Bremervörder Strasse 111, 21682, Stade, Lower Saxony, Germany. Holger.Schmidt@elbekliniken.de.

Funding

bioMé http://dx.doi.org/10.13039/501100022110
6 · The paper itself

Abstract

backgroundAn analysis of the cerebrospinal fluid (CSF) is essential for diagnosis of meningitis, headache, disturbance of conscience, cranial nerves or autoimmune-related conditions of the CNS. The initial treatment of pleocytosis usually consists of both antiviral therapy and antibiotics until laboratory results enable a more specific approach. Therefore, it is crucial to rapidly and accurately detect pathogens.

methodsIn this observatory, monocentric study of quality management data, we studied insourcing of ME-PCR, CXCL 13, Antibody-specific Index (AI) for HSV, VZV (G

resultsThe G

conclusionThe shortened average LOS after changing the diagnostic pathway increased direct costs for test kits. However, these costs were by far outweighed the economical benefit of being able to treat more patients in the same time. This analysis should be replicated in a different Medical Care System than the one in which this analysis has been calculated.

Indexed as

CSF-pleocytosisinflammatory CNS processLaboratory inhousingLaboratory outsourcingmeningoencephalitisME-PCRMulti ME PCR

Identifiers

PMID40542447
PMCPMC12180199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.