Observational studyThe journal of headache and pain2025
Inverse association of obesity with bout periodicity in episodic cluster headache: a multicenter cross-sectional study.
Observational study in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCluster headache (CH) is the most painful headache disorder. Despite a large body of evidence on obesity's negative influence on migraine, its impact on cluster headache disease activity remains unexplored. We aimed to determine whether body mass index (BMI) and obesity are associated with lifetime bout occurrence and annual bout frequency in patients with episodic cluster headache (ECH).
methodsThe Korean Cluster Headache Registry (KCHR) is a prospective, multicenter registry of consecutive patients with CH over 4 years. This cross-sectional study included 316 eligible patients with ECH, with ≥ 2 years of duration of CH disease and ≥ 2 times of lifetime bout occurrence. Obesity was determined using the Asia-Pacific classification (obese: BMI ≥ 25.0 kg/m
resultsThe mean (SD) age of the patients was 37 (9.7); 50 (15.8%) were female. The mean (SD) BMI was 23.9 (3.2) kg/m
conclusionsBMI and obesity were inversely associated with lifetime bout occurrence and annual bout frequency in ECH, suggesting that neurobiological aspects of obesity may suppress cluster bout periodicity.
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