Evidence map›Paper›PMID 40542387›Full record

ArticleAnimal microbiome2025

The impact of florfenicol treatment on the microbial populations present in the gill, intestine, and skin of channel catfish (Ictalurus punctatus).

Hongye Wang, Lina Sheng, Zeinab Yazdi, Xiran Li, Zhuosheng Liu, Sushumna Canakapalli, Yi Zhou, Chao Liao, Shiva Emami, Anita M Kelly and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hongye Wang *Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Lina Sheng *Department of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Zeinab YazdiSchool of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA.
Xiran LiDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Zhuosheng LiuDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Sushumna CanakapalliDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Yi ZhouDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Chao LiaoDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Shiva EmamiDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA.
Anita M KellySchool of Fisheries, Aquaculture & Aquatic Sciences, Auburn University, Auburn, AL, 3684, USA.
Luke A RoySchool of Fisheries, Aquaculture & Aquatic Sciences, Auburn University, Auburn, AL, 3684, USA.
Esteban SotoSchool of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA.
Luxin WangDepartment of Food Science and Technology, University of California Davis, One Shields Avenue, Davis, CA, 95616-5270, USA. lxwang@ucdavis.edu.

Funding

U.S. Department of Agriculture National Institute of Food and Agriculture under Grant #2019-06093-1022268
6 · The paper itself

Abstract

backgroundFlorfenicol is a broad-spectrum antimicrobial approved in many countries for treating bacterial infections in production animals. Although florfenicol has been widely used in the US catfish industry, its impact on the native microbiota within catfish tissues remains largely unknown. Florfenicol treatment is followed by a mandatory withdrawal period to ensure drug residues fall below regulatory limits before harvest. This interval also allows for the potential recovery of the native microbiota. In particular, the skin and gill microbiota have often been overlooked in aquaculture microbiome research. Moreover, the dynamics of microbial communities and resistome profiles following drug withdrawal are still poorly understood, despite their ecological significance.

resultsA significant increase in intestinal microbial diversity was observed at the end of the withdrawal period. The highest alpha diversity (Shannon index) was observed in catfish intestines. This increase indicated the restoration of the normal microbiota in catfish intestine. The predominant bacterial phyla shared among catfish gill, intestine, and skin are Proteobacteria (62%), Bacteroidetes (18%), Actinobacteriota (12%), Firmicutes (3%), Patescibacteria (2%), and Verrucomicrobiota (1%). Florfenicol application can have lasting effects through the withdrawal period, particularly altering the intestinal microbial community.

conclusionThe result of this study underscores the impact of florfenicol treatment on the bacterial landscape and antibiotic resistance in catfish, highlighting significant changes in microbial composition in the catfish intestine and at the end of the withdrawal period. These findings address the need for monitoring and managing antibiotic resistance in fish farming environments.

Indexed as

Antibiotic-resistant bacteriaCatfish microbiomeFishFlorfenicol

Identifiers

PMID40542387
PMCPMC12180268

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.