ArticleAnalytical and bioanalytical chemistry2025
Comprehensive lipid structure annotation via photochemical epoxidation and mass spectrometry.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Phospholipid Profiling Established by Structure-Rich Fragments for Molecular Species Level Shotgun Analysis.Rapid communications in mass spectrometry : RCM · 2026Article
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3 authors.
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Abstract
Cells tightly regulate lipid structures to fulfill cellular functions and to respond to external stimuli. The biochemical details of the processes that determine lipid structure alterations are often not fully understood. In this manuscript, we present a new epoxidation strategy of unsaturated lipids, which allows the annotation of lipid head group, fatty acid composition, C = C bond position, C = C bond geometry, and sn-isomerism when derivatized lipids are analyzed with corresponding separation and mass spectrometry methods. Tandem mass spectra of epoxidized deprotonated or protonated lipids provide information on head groups, fatty acids, and C = C positions, while MSⁿ of alkali metal adducts reveals sn-isomer compositions. Separation of epoxidation products via reversed-phase liquid chromatography (RPLC) not only distinguishes lipid C = C position and sn-isomers, remaining non-reacted unsaturated lipid C = C bonds photo-isomerize to reveal C = C E/Z configurations. To demonstrate the capabilities of the methodology, C = C positions of LPEs, LPCs, TGs, DGs, PCs, PSs, and PEs are annotated for bovine heart and liver extracts in RPLC-MS
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