Evidence map›Paper›PMID 40542214›Full record

ArticleNature aging2025

Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging.

Guoqiang Sun, Xiaolong Fu, Yandong Zheng, Guodong Hong, Ziyi Liu, Bilan Luo, Jinghui Lei, Dongliang Lv, Miao Chang, Yu Xiao and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  5. Review
  6. Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. [Research progress on the mechanism of auditory center remodeling and clinical intervention strategies in presbycusis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Guoqiang Sun *State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xiaolong Fu *Shandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID http://orcid.org/0000-0002-3884-0916
Yandong Zheng *State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Guodong Hong *Shandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Ziyi Liu *Shandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Bilan LuoAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing, China.
Jinghui LeiAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing, China.
Dongliang LvState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Miao ChangShandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Yu XiaoShandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Siwei GuoShandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID http://orcid.org/0000-0002-6496-4998
Shuai MaState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Ling LuDepartment of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, Southeast University, Nanjing, China.
Weiqi ZhangAging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0000-0002-8885-5104
Juan Carlos Izpisua BelmonteAltos Labs, San Diego, CA, USA.
Jing QuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.ORCID http://orcid.org/0000-0002-3988-5067
Si WangAging Biomarker Consortium (ABC), Beijing, China. wangsi@xwh.ccmu.edu.cn.ORCID http://orcid.org/0000-0003-2431-0612
Renjie ChaiAging Biomarker Consortium (ABC), Beijing, China. renjiec@seu.edu.cn.ORCID http://orcid.org/0000-0002-3885-543X
Guang-Hui LiuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.ORCID http://orcid.org/0000-0001-9289-8177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cochlear aging causes substantial hearing impairment in older adults, yet primate-specific mechanisms remain poorly characterized. Our comprehensive analysis combining single-cell and histopathological profiling in aging Macaca fascicularis demonstrates progressive cochlear degeneration featuring accelerated sensory hair cell loss, senescent spiral ganglion neurons with elevated neuroinflammation, and marked stria vascularis atrophy. We discovered that downregulation of transmembrane transport proteins, particularly SLC35F1, serves as a critical biomarker of hair cell aging. Functional validation through Slc35f1 knockdown in adult mice successfully recapitulated key aspects of age-related hearing loss, including hair cell degeneration and auditory function decline. Notably, we showed that long-term metformin administration at clinically relevant doses effectively delays cochlear aging in primates. These findings provide fundamental insights into the cellular and molecular basis of primate cochlear aging while establishing a foundation for developing targeted interventions against age-related hearing loss.

Indexed as

AgingCochleaPresbycusisAnimalsFemaleHair Cells, AuditoryHypoglycemic AgentsMacaca fascicularisMaleMembrane Transport ProteinsMetforminMiceNerve Tissue ProteinsSingle-Cell Gene Expression AnalysisSolute Carrier ProteinsHypoglycemic AgentsMembrane Transport ProteinsMetforminNerve Tissue ProteinsSLC35F1 protein, humanSlc35f1 protein, mouseSolute Carrier Proteins

Identifiers

PMID40542214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.