ArticleScientific reports2025
Exploring virulence factors, virulome, and multidrug resistance of Klebsiella pneumoniae strains isolated from patients with central Line-associated bloodstream infections.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Biofilm, virulence, and ESBL-mediated resistance: unmaskingMicrobiology spectrum · 2026Article
- Associations of Biofilm Capacity with Antimicrobial Resistance and Virulence Genes inAntibiotics (Basel, Switzerland) · 2026Article
- Klebsiella pneumoniae in the global AMR: resistance mechanisms and genomic adaptation.World journal of microbiology & biotechnology · 2026Review
- Outer Membrane Vesicles AttenuateMicroorganisms · 2025Article
- The mechanisms of antibiotic resistance and drug resistance transmission of Klebsiella pneumoniae.The Journal of antibiotics · 2025Review
- Epidemiology, Pathogenesis, Clinical Features, and Management of Non-HACEK Gram-Negative Infective Endocarditis.Antibiotics (Basel, Switzerland) · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to analyze the antibiotic resistance patterns and virulence profiles of Klebsiella pneumoniae, a prevalent gram-negative pathogen linked to CLABSI patients globally. Of a total of 185 microbial isolates, 51 (27.5%) were K. pneumoniae isolates. The results of antimicrobial susceptibility testing using the disk diffusion method were compared to those of the VITEK-2. Phenotypic analysis revealed that 88.3% were biofilm producers and 50.9% were extended-spectrum beta-lactamase (ESBL) producers. Enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) revealed a discriminatory power of 0.7111 between ten selected isolates. The PCR detection of the virulence genes, including FimH, rmpA, iutA, and fyuA, revealed that the ten selected isolates harbored all these genes, except one without the fyuA gene. The presence of the rmpA and the iutA genes confirmed them as hypervirulent (hv) K. pneumoniae. The genes (EAST-1, CNF-1) were present in 20% and 60% of the isolates, respectively. All isolates had the bla
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