Evidence map›Paper›PMID 40542124›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Epidemiology of bacterial and fungal infections among level IV neonatal units in North America.

Yo Nishihara, Isabella Zaniletti, Jeanne Zenge, Blair Weikel, Sarah Parker, Karna Murthy, Michael A Padula, Theresa Grover

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Urinary tract infection in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Research Progress on perinatalFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yo NishiharaSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. yo.nishihara@cuanschutz.edu.ORCID http://orcid.org/0009-0001-8110-7269
Isabella ZanilettiChildren's Hospitals Neonatal Consortium, Dover, DE, USA.ORCID http://orcid.org/0000-0003-1234-3468
Jeanne ZengeSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Blair WeikelSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Sarah ParkerSection of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Karna MurthyChildren's Hospitals Neonatal Consortium, Dover, DE, USA.
Michael A PadulaChildren's Hospitals Neonatal Consortium, Dover, DE, USA.
Theresa GroverSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal infections cause significant morbidity and mortality. A comprehensive analysis of bloodstream infections (BSI), urinary tract infections (UTI) and meningitis across level IV neonatal intensive care units (NICUs) is lacking.

methodsThis retrospective cohort study utilized data from the Children's Hospitals Neonatal Database (CHND) between January 2011 to December 2022. Patients with positive blood, urine, and cerebrospinal fluid (CSF) cultures were assessed. BSI trends across five geographic zones and a 10-year trend were studied.

resultsOf 172,921 patients, 15,541 (9.0%) had a culture-positive BSI, UTI, and/or meningitis. Within the 18,281 positive cultures (9794 BSI, 7097 UTI and 1390 CSF), 21,919 pathogens were identified. Infection rates were inversely related to gestational age. Pathogen distribution varied across regions, and over 10 years, Coagulase negative Staphylococcus declined, while E. coli and S. aureus proportions increased.

conclusionUnderstanding infection trends in level IV NICUs can inform targeted preventive strategies and quality improvement initiatives.

Indexed as

Bacterial InfectionsCross InfectionIntensive Care Units, NeonatalMycosesUrinary Tract InfectionsFemaleGestational AgeHumansInfant, NewbornMaleNorth AmericaRetrospective Studies

Identifiers

PMID40542124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.