Evidence map›Paper›PMID 40542119›Full record

ArticleScientific reports2025

Effects of taurine, brimonidine and betaxolol on oscillation modulation and stimulation efficiency in degenerated rd10 mouse retinas.

Kim Schaffrath, Claudia Ingensiep, Frank Müller, Peter Walter, Sandra Johnen

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kim SchaffrathDepartment of Ophthalmology, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. kischaffrath@ukaachen.de.
Claudia IngensiepDepartment of Ophthalmology, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Frank MüllerInstitute of Biological Information Processing, Molecular and Cellular Physiology (IBI-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany.
Peter WalterDepartment of Ophthalmology, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Sandra JohnenDepartment of Ophthalmology, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rd10 mouse is a widely used model for degenerative retinal diseases such as retinitis pigmentosa (RP). Its retina shows rhythmic spontaneous activity at a frequency of three to seven Hz, and the retinal ganglion cells (RGCs) are less electrically excitable. We hypothesize that the electrical excitability can be improved by suppressing the oscillations using the neuroprotective drugs 2-aminoethanesulphonic acid (taurine), brimonidine and betaxolol. These are involved in calcium homeostasis and may play a crucial role in neuroprotection and excitotoxicity by preventing Ca

Indexed as

BetaxololBrimonidine TartrateNeuroprotective AgentsRetinaRetinitis PigmentosaTaurineAnimalsDisease Models, AnimalElectric StimulationMiceRetinal Ganglion CellsBetaxololBrimonidine TartrateNeuroprotective AgentsTaurineMultielectrode arraysNeuroprotective substancesrd10 mouse modelRetinitis pigmentosa

Identifiers

PMID40542119
PMCPMC12181435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.