Evidence map›Paper›PMID 40542109›Full record

ReviewNature biomedical engineering2025

Strategies for the vascular patterning of engineered tissues for organ repair.

Kevin D Janson, Siavash Parkhideh, Joseph W R Swain, Jessica D Weaver, Jeffrey D Hartgerink, Omid Veiseh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kevin D Janson *Department of Bioengineering, Rice University, Houston, TX, USA.
Siavash Parkhideh *Department of Bioengineering, Rice University, Houston, TX, USA.
Joseph W R SwainDepartment of Chemistry, Rice University, Houston, TX, USA.
Jessica D WeaverSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Jeffrey D HartgerinkDepartment of Bioengineering, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3186-5395
Omid VeisehDepartment of Bioengineering, Rice University, Houston, TX, USA. omid.veiseh@rice.edu.ORCID http://orcid.org/0000-0003-1153-8079

Funding

Synthesis and High-Throughput In Vivo Characterization of Alginate Encapsulation Materials for Long-Term IsletR01DK120459 · NIDDK · RICE UNIVERSITY · PI VEISEH, OMID · 2018 to 2021
$2.9M
JDRF 3-SRA-2022-1255-S-BJDRF 3-SRA-2024-1564-S-BJDRF 3-SRA-2025-1640-S-BJDRF grant JDRF 3-SRA-2021-1023-S-BJDRF SRA-2023-1398-S-BUnited States Department of Defense | Defense Advanced Research Projects Agency (DARPA) AWD00001596United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) FA8650-21-1-7119U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK120459
6 · The paper itself

Abstract

The loss of organ function following traumatic injury is often irreversible and the demand for organ replacements continues to exceed supply. This discrepancy has driven the development of therapies and engineered tissues for the repair or replacement of damaged tissues. However, the survival of engineered tissues is constrained by the challenge of establishing a functional vasculature. Efforts have therefore focused on strategies that induce vascularization in tissue implants or stimulate vascular growth in recipients of the therapies. Here we discuss recent advances in vascular biology, biomaterials chemistry and 3D printing techniques for vascular patterning in engineered tissues. For tissue regeneration to be clinically viable, vascular formation must be guided across scales ranging from micrometres to millimetres through biological, chemical and physical approaches.

Indexed as

Blood VesselsNeovascularization, PhysiologicTissue EngineeringAnimalsBiocompatible MaterialsHumansPrinting, Three-DimensionalTissue ScaffoldsBiocompatible Materials

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.