Evidence map›Paper›PMID 40542108›Full record

ReviewNature biomedical engineering2025

Multiplexed imaging of radionuclides.

Georgios Soultanidis, Joaquin L Herraiz, Zahi A Fayad, Jan Grimm, Abraham J P Teunissen

Abstract readReview
In one paragraph

Review in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Immuno-imaging in solid organ transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Review
  3. Article
  4. Review
  5. Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Georgios Soultanidis *Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joaquin L Herraiz *Nuclear Physics Group and IPARCOS, Complutense University of Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-7208-8863
Zahi A FayadBiomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3439-7347
Jan GrimmMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5282-9385
Abraham J P TeunissenBiomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. bram.teunissen@mssm.edu.ORCID http://orcid.org/0000-0002-0401-8262

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Li Shen · 2017 to 2026
$24.3M
Using trained immunity-inhibiting nanobiologics to achieve tolerance of heart allografts in non-human primatesP01AI168258 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad, Joren C Madsen · 2023 to 2026
$14.7M
Multicolor PET to interrogate cancer biologyR01EB033000 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI Jan Grimm, Vladimir Ponomarev · 2023 to 2026
$2.6M
NCI NIH HHS P30 CA008748NHLBI NIH HHS P01 HL131478NIAID NIH HHS P01 AI168258NIBIB NIH HHS R01 EB033000U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1R01CA220234-01A1U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1P01AI168258-01
6 · The paper itself

Abstract

Nuclear imaging provides non-invasive and near-quantitative insight into the biodistribution of radiolabelled compounds, and it does so with exceptional sensitivity and practically unlimited penetration depth. These properties make nuclear imaging highly valuable for monitoring the pharmacokinetics, biodistribution and in vivo stability of therapeutics. Moreover, the diversity of radioactive probes allows for detailed insight into cell dynamics, metabolism, epigenetics and other biological processes. However, nuclear imaging remains largely limited to single-tracer studies, or to the sequential imaging of each tracer. Tracking only a single probe or compound at a time limits the insight that can be gained. Here we discuss the applications and clinical feasibility of established and upcoming strategies for the simultaneous imaging of multiple radiotracers.

Indexed as

RadioisotopesRadiopharmaceuticalsAnimalsHumansPositron-Emission TomographyTissue DistributionRadioisotopesRadiopharmaceuticals

Identifiers

PMID40542108
PMCPMC12314712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.