Evidence map›Paper›PMID 40542102›Full record

ArticleScientific reports2025

Birth mode is associated with layer-specific mechanical changes in fetal membranes.

Philip Friedrich, Hanna Grubitzsch, Benjamin Wolf, Hannah M Eichholz, Cary Tutmarc, Pablo Gottheil, Frank Sauer, Alissa Cornelis, Anne-Sophie Wegscheider, Bahriye Aktas and 2 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Philip Friedrich *Peter Debye Institute for Soft Matter Physics, Leipzig University, 04103, Leipzig, Germany.
Hanna Grubitzsch *Department of Obstetrics, University Hospital Leipzig, 04103, Leipzig, Germany.
Benjamin WolfDepartment of Gynecology, University Hospital Leipzig, 04103, Leipzig, Germany.
Hannah M EichholzPeter Debye Institute for Soft Matter Physics, Leipzig University, 04103, Leipzig, Germany.
Cary TutmarcPeter Debye Institute for Soft Matter Physics, Leipzig University, 04103, Leipzig, Germany.
Pablo GottheilPeter Debye Institute for Soft Matter Physics, Leipzig University, 04103, Leipzig, Germany.
Frank SauerPeter Debye Institute for Soft Matter Physics, Leipzig University, 04103, Leipzig, Germany.
Alissa CornelisDepartment of Obstetrics, University Hospital Leipzig, 04103, Leipzig, Germany.
Anne-Sophie WegscheiderInstitute for Histology, Cytology and Molecular Diagnostics, MVZ Prof. Dr. Med. A. Niendorf Pathologie Hamburg-West GmbH, 22767, Hamburg, Germany.
Bahriye AktasDepartment of Gynecology, University Hospital Leipzig, 04103, Leipzig, Germany.
Josef A Käs *Peter Debye Institute for Soft Matter Physics, Leipzig University, 04103, Leipzig, Germany.
Holger Stepan *Department of Obstetrics, University Hospital Leipzig, 04103, Leipzig, Germany. Holger.Stepan@medizin.uni-leipzig.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rupture of fetal membranes and subsequent full-term birth are prerequisites for neonatal health, and a preterm rupture can lead to life-threatening complications. Our study determines the mechanical properties of term fetal membranes to identify perinatal structural changes by a unique biophysical multiscale approach, including atomic force microscopy, shear rheology, tabletop magnetic resonance elastography (MRE), and high-resolution optical microscopy. Fetal membranes from term spontaneous vaginal deliveries were compared to those from primary cesarean sections, used as a control group for pre-labor membranes. Spontaneously delivered term fetal membranes are softer and easier to deform in MRE experiments (median stiffness: 1.9 kPa, IQR 1.6-2.4) compared to controls (4.7 kPa, IQR 3.8-5.6); p < 0.001) and show increased water diffusion (median: 1.78 × 10

Indexed as

Extraembryonic MembranesAdultBiomechanical PhenomenaElasticity Imaging TechniquesFemaleHumansInfant, NewbornMicroscopy, Atomic ForcePregnancyPremature Rupture of Fetal MembranesAtomic force microscopyFetal membranesMagnetic resonance elastographyRupture of membranesShear rheologyTissue viscoelasticity

Identifiers

PMID40542102
PMCPMC12181243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.