Evidence map›Paper›PMID 40542044›Full record

ArticleScientific reports2025

Suprachoroidal implantation of corticosteroid slow release implants for the treatment of cystoid macular edema.

Ben Asani, Franziska Kruse, Jakob Siedlecki, Johannes Benedikt Schiefelbein, Benedikt Schworm, Julian Klaas, Tina Herold, Siegfried G Priglinger

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ben AsaniDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany. ben.asani@med.uni-muenchen.de.
Franziska KruseDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.
Jakob SiedleckiDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.
Johannes Benedikt SchiefelbeinDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.
Benedikt SchwormDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.
Julian KlaasDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.
Tina HeroldDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.
Siegfried G PriglingerDepartment of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cases of an unstable iris-lens diaphragm, intravitreal corticosteroid slow-release implants (CSRI) may accidentally migrate into the anterior chamber, leading to damage to the corneal endothelium. The purpose of this study was to evaluate the efficacy and safety of a suprachoroidal application of these primarily intravitreal implants to address this issue. In this single-center, retrospective proof of principle study, we observed consecutive cases of patients receiving dexamethasone and fluocinolon acetonide implants that were administered into the suprachoroidal space in patients with CME and instability of the iris-lens diaphragm. Treatment responses of the CME on OCT, incidence of secondary intraocular pressure increases, visual acuity and surgery related complications were evaluated. In total, 16 patients were treated. and mean follow up was 1.8 ± 0.97 months. The procedure was well tolerated with no severe intraoperative or postoperative side effects. Mean central retinal thickness (CRT) decreased significantly from 563.13 to 382.12 (p = 0.002). There was no incidence of steroid induced glaucoma. Mean best corrected visual acuity (BCVA) significantly improved from 1.07 logMAR to 0.65 logMAR (p = 0.01). Suprachoroidal implantation of corticosteroid slow-release implants proves to be a safe and feasible alternative for complex eyes with CME and a disruption of the anterior-posterior segment border.

Indexed as

Adrenal Cortex HormonesDrug ImplantsMacular EdemaAgedChoroidDelayed-Action PreparationsDexamethasoneFemaleFluocinolone AcetonideHumansIntraocular PressureMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeAdrenal Cortex HormonesDelayed-Action PreparationsDexamethasoneDrug ImplantsFluocinolone AcetonideAphakiaCystoid macular edemaImplant dislocationSuprachoroidal implant

Identifiers

PMID40542044
PMCPMC12181378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.