Evidence map›Paper›PMID 40542037›Full record

ArticleScientific reports2025

A mobile robot bridging manual and automated bioscientific workflows by applying the Swiss army knife principle.

Nicole Rupp, Rebecca Wienbruch, Julia Esther Gröber, Michael Köppl, Ruven Dreischke, Larissa Ballardt, Klaus König, Thole Zuchner

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole RuppFaculty for Life Sciences, Professorship for Bioanalytics and Laboratory Automation, Albstadt-Sigmaringen University, Anton-Günther-Str. 51, 72488, Sigmaringen, Germany.ORCID http://orcid.org/0000-0002-7967-1346
Rebecca WienbruchFaculty for Life Sciences, Professorship for Bioanalytics and Laboratory Automation, Albstadt-Sigmaringen University, Anton-Günther-Str. 51, 72488, Sigmaringen, Germany.ORCID http://orcid.org/0009-0006-6649-9280
Julia Esther GröberFaculty for Life Sciences, Professorship for Bioanalytics and Laboratory Automation, Albstadt-Sigmaringen University, Anton-Günther-Str. 51, 72488, Sigmaringen, Germany.
Michael Köppl8-BOT Robotics, Schiffstr. 46, 78464, Konstanz, Germany.
Ruven Dreischkejetzt-GmbH, Bücklestrasse 3, 78467, Konstanz, Germany.
Larissa BallardtFaculty for Life Sciences, Professorship for Bioanalytics and Laboratory Automation, Albstadt-Sigmaringen University, Anton-Günther-Str. 51, 72488, Sigmaringen, Germany.
Klaus Königjetzt-GmbH, Bücklestrasse 3, 78467, Konstanz, Germany.
Thole ZuchnerFaculty for Life Sciences, Professorship for Bioanalytics and Laboratory Automation, Albstadt-Sigmaringen University, Anton-Günther-Str. 51, 72488, Sigmaringen, Germany. zuechner@hs-albsig.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complexity and diversity of bioscientific research laboratories, creates significant challenges for automation. Their varying workflows, personnel, and instruments, often hinder smaller research laboratories to benefit from automated processes, as existing systems seem unsuitable due to low flexibility. Therefore, we developed a versatile robotic system designed to automate a broad range of bioscience laboratory processes. Central to our system and novel, compared to all other kinds of laboratory automation concepts, is a multifunctional end effector, inspired by the Swiss-army-knife, capable of executing multiple tasks, including an operating finger, a camera system, a gripper, and a pipette. This end effector is mounted on a 6-axis robotic arm, supported by a mobile base, enabling easy transport across different bioanalytical laboratory environments. Utilizing windows manipulating scripting routines, allows the automation of diverse software programs including software-based laboratory devices. We demonstrate the capabilities of the Laboratory Automation Robotic System (LARS) by automating the pH buffer adjustments, showcasing its potential to improve efficiency and reproducibility in bioscience research. The resulting prototype allows the integration of any laboratory instrument into a desired automation routine without limitations concerning device interfaces, while using a highly flexible multifunctional end-effector as a replacement of the human hand and eye.

Indexed as

Automation, LaboratoryRoboticsWorkflowAutomationHumansSoftwareBioanalytical processesCamera-basedLaboratory automationMultifunctionalQuality improvementRobotic system

Identifiers

PMID40542037
PMCPMC12181227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.