Evidence map›Paper›PMID 40541987›Full record

ArticleScientific reports2025

Analysis and simulation of a novel stochastic RNA silencing model.

Ragaa Ahmed, Hillal M Elshehabey

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ragaa AhmedDepartment of Mathematics, Faculty of Science, South Valley University, Qena, 83523, Egypt.
Hillal M ElshehabeyDepartment of Mathematics, Faculty of Science, South Valley University, Qena, 83523, Egypt. hilal.hilal@sci.svu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current work aims to investigate how random environmental fluctuations affect the dynamics of the RNA Silencing model. To capture this complexity, a novel stochastic RNA Silencing model is proposed by incorporating four distinct white noise terms into key system parameters. Unlike previous deterministic approaches, our model explicitly accounts for stochastic perturbations using Brownian motion processes. A comprehensive analysis of both the deterministic as well as the stochastic one are presented. Employing Lyapunov analysis, the stochastic system yields a unique global positive solution for any initial value, ensuring its biological relevance. Lastly, numerical simulations based on the Milstein's higher-order-method are conducted for the two models. The findings highlight the significant influence of stochasticity on RNA silencing dynamics, offering new insights into the stability and behavior of gene regulatory processes under random fluctuations.

Indexed as

Models, GeneticRNA InterferenceComputer SimulationStochastic ProcessesExistence and uniquenessLyapunov functionRNAStochastic modelWhite noise

Identifiers

PMID40541987
PMCPMC12181426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.