Evidence map›Paper›PMID 40541955›Full record

ArticleNPJ Parkinson's disease2025

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.

Sissel Ida Schmidt, Justyna Okarmus, Daniel Aghaie Madsen, Julie Schmidt Hansen, Emil Gregersen, Hjalte Gram, Lucas S Winkelmann, Anderson Souza Oliveira, Rachel Heon-Roberts, Brent J Ryan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Rethinking Mitochondrial Parkinson's Disease in the α-Synuclein Seed Amplification Assays Era.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sissel Ida SchmidtDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Justyna OkarmusDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Daniel Aghaie MadsenDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Julie Schmidt HansenDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Emil GregersenDANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Hjalte GramDANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Lucas S WinkelmannDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Anderson Souza OliveiraDepartment of Materials and Production, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark.
Rachel Heon-RobertsOxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Brent J RyanOxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Kristine FreudeFaculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen, Copenhagen, Denmark.
Morten BlaabjergDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Poul Henning JensenDANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Morten MeyerDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. mmeyer@health.sdu.dk.

Funding

Independent Research Fund Denmark 4285-00369BLundbeck Foundation R223-2015-4222 and R248-2016-2518
6 · The paper itself

Abstract

Loss-of-function mutations in PARK2 (parkin) cause early-onset familial Parkinson's disease (PD) and may also contribute to sporadic PD. While Lewy bodies, enriched in aggregated phosphorylated α-synuclein (α-Syn), are typical in PD, their presence in PARK2-mediated PD remains debated. Using human isogenic PARK2

Identifiers

PMID40541955
PMCPMC12181250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.