Evidence map›Paper›PMID 40541943›Full record

ArticleNature communications2025

Iron deficiency causes aspartate-sensitive dysfunction in CD8

Megan R Teh, Nancy Gudgeon, Joe N Frost, Linda V Sinclair, Alastair L Smith, Christopher L Millington, Barbara Kronsteiner, Jennie Roberts, Bryan P Marzullo, Hannah Murray and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Metal Ions Within the Neuro-Immune-Tumor Axis.Journal of immunology research · 2026
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Megan R TehMRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. mteh@cemm.oeaw.ac.at.ORCID http://orcid.org/0000-0002-8095-9961
Nancy GudgeonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-0396-5241
Joe N FrostMRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5946-6062
Linda V SinclairDivision of Cell Signalling and Immunology, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0003-1248-7189
Alastair L SmithMRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6330-1407
Christopher L MillingtonMRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0007-9219-0946
Barbara KronsteinerNuffield Department of Clinical Medicine, NDM Centre for Global Health Research, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0867-2867
Jennie RobertsSchool of Medical Sciences, College of Medicine and Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Bryan P MarzulloSchool of Medical Sciences, College of Medicine and Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-1874-6906
Hannah MurrayMRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Alexandra E PrestonMRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0008-5916
Victoria StavrouInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0009-0009-3245-4967
Jan RehwinkelMRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Thomas A MilneMRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0413-4271
Daniel A TennantSchool of Medical Sciences, College of Medicine and Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-0499-2732
Susanna J DunachieNuffield Department of Clinical Medicine, NDM Centre for Global Health Research, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5665-6293
Andrew E ArmitageMRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5977-6602
Sarah Dimeloe *Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-4598-6518
Hal Drakesmith *MRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. alexander.drakesmith@ndm.ox.ac.uk.ORCID http://orcid.org/0000-0002-8503-6103

Funding

Cancer Research UK (CRUK) C42109/A24757RCUK | Medical Research Council (MRC) MCU_12010/10Wellcome TrustWellcome Trust (Wellcome) 205023/Z/16/Z
6 · The paper itself

Abstract

Iron is an irreplaceable co-factor for metabolism. Iron deficiency affects >1 billion people and decreased iron availability impairs immunity. Nevertheless, how iron deprivation impacts immune cell function remains poorly characterised. We interrogate how physiologically low iron availability affects CD8

Indexed as

Aspartic AcidCD8-Positive T-LymphocytesIron DeficienciesAnimalsCell ProliferationCitric Acid CycleFemaleGlucoseGlutamineHistonesHumansIronMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLAspartic AcidGlucoseGlutamineHistonesIron

Identifiers

PMID40541943
PMCPMC12181297

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.