Evidence map›Paper›PMID 40541605›Full record

ArticleNeuroscience letters2025

C1ql3 promotes cognitive flexibility behavior in mice.

Keaven Caro, Trevor Religa, Shahnawaz Alam, Mark H Cristino, Maya Preibisz-Kamat, James R Rybczyk, Hiu W Cheung, Maksym V Ugrak, Timothy Spellman, David C Martinelli

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In one paragraph

Article in Neuroscience letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keaven CaroDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Trevor ReligaDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA; The Connecticut Institute for the Brain and Cognitive Sciences (IBACS), Storrs, CT, USA.
Shahnawaz AlamDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Mark H CristinoDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Maya Preibisz-KamatDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
James R RybczykDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Hiu W CheungDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Maksym V UgrakDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Timothy SpellmanDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA; The Connecticut Institute for the Brain and Cognitive Sciences (IBACS), Storrs, CT, USA.
David C MartinelliDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA; The Connecticut Institute for the Brain and Cognitive Sciences (IBACS), Storrs, CT, USA. Electronic address: martinelli.uchc@gmail.com.

Funding

Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training ProgramT32AR079114 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2021 to 2025
$1.1M
The Molecular Role of C1QL3 and its Binding Partners in Synaptic RegulationF30MH135628 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CARO, KEAVEN DELWYN JACOB · 2024 to 2025
$100k
NIAMS NIH HHS T32 AR079114NIMH NIH HHS F30 MH135628
6 · The paper itself

Abstract

Cognitive flexibility, the ability to adapt behavioral strategies based on changing circumstances, is deficient in patients with certain neuropsychiatric disorders, such as autism spectrum disorder and schizophrenia. Cognitive flexibility can be measured in humans and animal models using attentional set-shifting tasks, which require activity of the prefrontal cortex (PFC) and other key brain regions. We demonstrate that C1QL3, a protein involved in regulating excitatory synapse density in the PFC and other brain circuits, is important for attentional set-shifting, using a mouse model of C1ql3 disruption. Conditional deletion of C1ql3 from neurons specifically in the PFC of adult mice was not sufficient to impair attentional set-shifting behavior, highlighting the potential role of C1ql3 in promoting cognitive flexibility through expression in other key brain circuits and/or neurodevelopmental processes.

Indexed as

CognitionComplement C1qPrefrontal CortexAnimalsAttentionBehavior, AnimalCognitive FlexibilityMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsComplement C1qAttentional set-shiftingCognitive flexibilityCtrp13SynapseTrans-synaptic

Identifiers

PMID40541605
PMCPMC12270346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.