ArticleCell genomics2025
A rare, evolutionarily conserved venom protein benefits endoparasitism across parasitoids.
Article in Cell genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Venom vesicles from the parasitoid Ganaspis hookeri facilitate venom protein entry into host immune cells.PLoS pathogens · 2026Article
- Transforming hosts into nurseries and nutrients: strategic manipulation by endoparasitoid wasps.Journal of advanced research · 2026Review
- Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- A bacterial gene acquired by parasitoid wasps contributes to venom secretion against host defence.The EMBO journal · 2026Article
- Chromosomes ofComparative cytogenetics · 2026Article
- ThebioRxiv : the preprint server for biology · 2025Article
- Rethinking parasitoid venoms: beyond immune suppression.Trends in parasitology · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many venom proteins and other parasitic effectors have been identified in various specific systems of parasitoids, key elements that contribute to parasitic success across a broad range of taxa remain largely unexplored. Here, we focus on Leptopilina and conduct a large-scale, multi-omics study to explore common venom proteins for these drosophilid parasitoids. We find that this genus has undergone extensive chromosome rearrangements and a rapid turnover of venom gene repertoires between species. Interestingly, we identified a lineage-specific venom lipase, Leptopilina-specific venom lipase (LVL), as a rare venom protein that is subject to evolutionary constraint and recruited by all Leptopilina species. Functional genetics studies on LVL reveal its critical role in hydrolyzing host lipids under acidic conditions, which in turn ensures the nutrition supply for the embryonic development of parasitoids. Our study provides a paradigm to characterize adaptive effectors across diverse insects and highlights the importance of host lipid utilization in the parasitization of parasitoids.
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