Evidence map›Paper›PMID 40541059›Full record

ArticleParkinsonism & related disorders2025

Including individuals with Parkinson's disease and deep brain stimulation in rehabilitation trials: feasibility, challenges, and preliminary gait and postural stability results.

Anson B Rosenfeldt, Sara Davidson, Ryan D Kaya, Elizabeth West, James Y Liao, Benjamin L Walter, Hubert Fernandez, Jay L Alberts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anson B RosenfeldtCleveland Clinic, Lerner Research Institute, Department of Biomedical Engineering, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Sara DavidsonCleveland Clinic, Neurological Institute, Center for Neurological Restoration, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Ryan D KayaCleveland Clinic, Neurological Institute, Center for Neurological Restoration, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Elizabeth WestCleveland Clinic, Lerner Research Institute, Department of Biomedical Engineering, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
James Y LiaoCleveland Clinic, Neurological Institute, Center for Neurological Restoration, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Benjamin L WalterCleveland Clinic, Neurological Institute, Center for Neurological Restoration, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Hubert FernandezCleveland Clinic, Neurological Institute, Center for Neurological Restoration, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
Jay L AlbertsCleveland Clinic, Lerner Research Institute, Department of Biomedical Engineering, 9500 Euclid Ave., Cleveland, OH, 44195, USA; Cleveland Clinic, Neurological Institute, Center for Neurological Restoration, 9500 Euclid Ave., Cleveland, OH, 44195, USA. Electronic address: albertj@ccf.org.

Funding

Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
The Cyclical Lower-extremity Exercise for Parkinson's TrialR01NS073717 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2011 to 2023
$4.8M
The impact of exercise on subthalamic nucleus neural activity in Parkinson's diseaseR21NS129147 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2022 to 2023
$443k
NCATS NIH HHS UM1 TR004528NINDS NIH HHS R01 NS073717NINDS NIH HHS R21 NS129147
6 · The paper itself

Abstract

backgroundPeople with Parkinson's disease (PwPD) who have undergone deep brain stimulation (DBS) surgery have been historically excluded from rehabilitation clinical trials.

objectiveThis project investigated the safety, feasibility, and preliminary efficacy of a dual-task training intervention aimed at improving postural instability and gait dysfunction (PIGD) in PwPD with DBS.

methodsSymptoms of PIGD were measured with the 2-Minute Walk Test (2MWT) and Timed Up and Go (TUG) test under single- and dual-task conditions.

resultsFive participants completed 97.5 % of the 16 intervention sessions without serious adverse events. One participant was excluded from the motor analysis due to frequent changes in DBS settings. Of the four participants included in the analysis, all demonstrated improvement in the TUG under single- and dual-task conditions. During the 2MWT, two participants experienced an improvement in gait speed under single-task conditions, and three experienced an improvement under dual-task conditions.

conclusionInitial data suggest dual-task training is safe and feasible for PwPD with DBS. Having DBS presents unique challenges including advanced motor symptoms, autonomic dysfunction, and potential changes in DBS parameters, that impact intervention delivery, adherence, and outcomes. Despite unique challenges, appropriately selected PwPD with DBS have the capacity to improve PIGD symptoms with dual-task training. To facilitate generalizability across the PD continuum, future rehabilitation trials including PwPD with DBS are justified and recommended.

Indexed as

Deep Brain StimulationGait Disorders, NeurologicParkinson DiseasePostural BalanceAgedFeasibility StudiesFemaleHumansMaleMiddle AgedDeep brain stimulationDual-task trainingGaitParkinson's diseasePostural instabilityRehabilitation

Identifiers

PMID40541059
PMCPMC13003424

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.