ReviewAnnual review of biochemistry2025
Nonlytic Egress and Transmission in the Virus World.
Review in Annual review of biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Natural and evolved membrane-associated accessory proteins differentially engage SNARE machinery for AAV egress.Journal of virology · 2026Article
- Transcriptional and Alternative Splicing Regulation of Autophagy and Vesicle Transport Pathways in Large Yellow Croaker Cells During Megalocytivirus Infection.Animals : an open access journal from MDPI · 2026Article
- Nisin bacteriocin blocks T. denticola-triggered MMP2 activation and pathogen internalization via TLR2.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Viruses must egress from the cells in which they have replicated to spread and propagate. Historically, viruses have been classified into enveloped and nonenveloped forms: Enveloped viruses exploit cellular membrane-trafficking pathways to egress while maintaining cell integrity, and nonenveloped viruses, i.e., those lacking a membrane around their capsids, lytically egress. Here, we make the compelling case that all animal and plant and many archaeal and bacterial viruses egress through nonlytic pathways. Most of these nonlytic pathways can be separated into those that enable viruses to spread without leaving the confines of cell bodies and those that traffic them to the extracellular space in enveloped membrane-bound forms. Nonlytic egress pathways bestow viruses with distinct transmission advantages including high multiplicity of infection, quality control over transmitting infectious units, and evasion of innate and adaptive antiviral immune defense mechanisms.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.