ReviewAging and disease2025
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions.
Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders, primarily characterized by cognitive decline and motor dysfunction, respectively. The comorbidity of AD and PD further increases disease complexity and presents significant challenges for clinical diagnosis and treatment. Due to substantial clinical overlaps in the advanced stage of AD and PD, comorbid cases are frequently misdiagnosed as a single disease, which hinders early recognition and timely intervention. Based on pathological observations from patients with comorbidity of AD and PD, this review discusses the prevalence and clinical features of AD-PD comorbidity, the spatiotemporal progression and potential interactions of key pathological proteins, including β-amyloid (Aβ), phosphorylated tau (pTau), and α-synuclein (α-syn). The aim of this review is to update potential new insights and strategies to improve diagnostic accuracy, advance personalized therapeutic approaches, and guide future research into the underlying mechanisms of comorbidity.
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Registered trials
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