Evidence map›Paper›PMID 40540670›Full record

Observational studyAnnals of the American Thoracic Society2025

Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in 6- to 11-Year-Olds with Cystic Fibrosis: An Observational Study.

Jessica E Pittman, Sarah Morgan, Morgan McCreary, Phuong T Vu, Peter Jorth, Sonya Heltshe, Lucas R Hoffman, Andrea Kelly, Scott D Sagel, Pradeep K Singh and 4 more

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Annals of the American Thoracic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Observational
  3. Observational
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jessica E PittmanDepartment of Pediatrics, School of Medicine, Washington University, St. Louis, Missouri.
Sarah MorganDepartment of Microbiology, and.
Morgan McCrearyCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center and.
Phuong T VuCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center and.
Peter JorthDepartment of Pathology and Laboratory Medicine.ORCID 0000-0002-0981-740X
Sonya HeltsheDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
Lucas R HoffmanDepartment of Microbiology, and.ORCID 0000-0001-8864-6751
Andrea KellyDivision of Endocrinology and Diabetes, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Scott D SagelDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-6172-4465
Pradeep K SinghDepartment of Microbiology, and.
George M SolomonDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Margaret RosenfeldDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
Felix RatjenDivision of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
PROMISE Pediatric substudy Investigators

Funding

Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Patient-oriented microbiome and advanced culture approaches to identifying the microbial determinants of chronic pediatric diseaseK24HL141669 · NHLBI · UNIVERSITY OF WASHINGTON · PI Lucas R Hoffman · 2018 to 2026
$929k
Cystic Fibrosis Foundation TDNCC18K0NCATS NIH HHS UM1 TR004399NHLBI NIH HHS K24 HL141669NIDDK NIH HHS P30 DK072482NIDDK NIH HHS P30 DK089507NIH HHS UM1 TR004399University of Alabama at Birmingham P30DK072482
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminophenolsBenzodioxolesCystic FibrosisIndolesPyrazolesPyridinesQuinolonesChildChloride Channel AgonistsCystic Fibrosis Transmembrane Conductance RegulatorDrug CombinationsFemaleForced Expiratory VolumeHumansMaleProspective StudiesAminophenolsBenzodioxolesChloride Channel AgonistsCystic Fibrosis Transmembrane Conductance RegulatorDrug Combinationselexacaftor, ivacaftor, tezacaftor drug combinationIndolesPyrazolesPyridinesQuinolinesQuinolonesbacterial infectioncystic fibrosiscystic fibrosis transmembrane conductance regulator modulatorlung function

Identifiers

PMID40540670
PMCPMC12393130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.