Evidence map›Paper›PMID 40540646›Full record

ArticleJournal of agricultural and food chemistry2025

Analysis of Honey and Environmental Samples from BEN Endemic Villages in Serbia: Identification of a Novel Human Exposure Pathway for Aristolochic Acids and Aristolactams.

Chun-Kit Au, Man-Lung Chin, Wing-Laam Luk, Ka-Wa Wong, Ling-Yung Che, Bi-Feng Yuan, Goran Ilić, Miljana Pavlović, Ho-Wai Chan, Jian Zhen Yu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chun-Kit AuDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.ORCID 0000-0002-2204-4907
Man-Lung ChinDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.
Wing-Laam LukDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.
Ka-Wa WongDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.
Ling-Yung CheDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.
Bi-Feng YuanDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0001-5223-4659
Goran IlićInstitute of Forensic Medicine, Faculty of Medicine, University of Niš, Niš 18000, Serbia.
Miljana PavlovićDepartment of Anatomy, Faculty of Medicine, University of Niš, Niš 18000, Serbia.
Ho-Wai ChanDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.
Jian Zhen YuDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.ORCID 0000-0002-6165-6500
Nikola M PavlovićMedical Faculty, University of Niš, Bulevar Dr Zorana D̵ind̵ića 81, Niš 18000, Serbia.
Zongwei CaiEastern Institute of Technology Ningbo, Ningbo, Zhejiang 315200, China.ORCID 0000-0002-8724-7684
Wan ChanDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong.ORCID 0000-0001-8479-3172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary exposure to aristolochic acids (AAs) through AA-tainted flour is closely linked to the development of Balkan endemic nephropathy (BEN), a chronic kidney disease that is prevalent in rural farming villages in the Balkan region; however, additional exposure pathways would better explain the incidence rate of BEN. This study reveals for the first time that inhalation of AA-contaminated air, which often contains aristolactams (ALs)─genotoxic metabolites of AAs─represents an unrecognized exposure route. The presence of AAs was confirmed in local honey, and subsequent analysis of face masks worn by volunteers near flowering

Indexed as

Air PollutantsAristolochiaAristolochic AcidsBalkan NephropathyHoneyHumansSerbiaAir PollutantsAristolochic Acidsair pollutionaristolactamsaristolochic acidBalkan endemic nephropathybiomass burning

Identifiers

PMID40540646
PMCPMC12322912

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.