Evidence map›Paper›PMID 40540587›Full record

ArticleScience immunology2025

A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.

Sanmoy Pathak, Thea Hogan, Sanket Rane, Yundi Huang, Claire Pearson, Charles Sinclair, Simon Barry, Larissa Carnevalli, Andrew J Yates, Benedict Seddon

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sanmoy PathakInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Hospital, London, UK.ORCID 0000-0001-6137-8718
Thea HoganInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Hospital, London, UK.
Sanket RaneDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA.ORCID 0000-0003-2612-4725
Yundi HuangInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Hospital, London, UK.ORCID 0009-0004-3798-5971
Claire PearsonKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID 0000-0001-5816-1657
Charles SinclairAstraZeneca, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0001-6857-9993
Simon BarryAstraZeneca, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-8511-0588
Larissa CarnevalliAstraZeneca, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0001-7432-0195
Andrew J YatesDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA.ORCID 0000-0003-4606-4483
Benedict SeddonInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Hospital, London, UK.ORCID 0000-0003-4352-3373

Funding

Modeling the development, structure and regulation of T cell memoryR01AI093870 · NIAID · UNIVERSITY OF GLASGOW · PI YATES, ANDREW · 2011 to 2025
$5.9M
Modeling the ecology of tissue-resident T cellsU01AI150680 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L., YATES, ANDREW · 2020 to 2024
$5.0M
NIAID NIH HHS R01 AI093870NIAID NIH HHS U01 AI150680
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

Immunologic MemoryLymphocytes, Tumor-InfiltratingMemory T CellsT-Lymphocytes, RegulatoryAnimalsMiceMice, Inbred C57BLMice, TransgenicThymus Gland

Identifiers

PMID40540587
PMCPMC13004003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.