Evidence map›Paper›PMID 40540580›Full record

ArticleScience advances2025

Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in

Jessica A Kirshner, Colette L Picard, Natasha E Weiser, Nicita Mehta, Suhua Feng, Victoria N Murphy, Anna Vakhnovetsky, Amelia F Alessi, Connie Xiao, Kai Inoki and 4 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jessica A KirshnerDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0004-3364-5312
Colette L PicardDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2177-2216
Natasha E WeiserDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9971-2961
Nicita MehtaDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-7623-0580
Suhua FengDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
Victoria N MurphyDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4501-3772
Anna VakhnovetskyDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.
Amelia F AlessiDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.
Connie XiaoDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.
Kai InokiDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0007-0191-7928
Sonia El MouridiKing Abdullah University of Science and Technology, Biological and Environmental Epigenetics Program, Thuwal, Saudi Arabia.ORCID 0000-0002-3674-3151
Christian Frøkjær-JensenKing Abdullah University of Science and Technology, Biological and Environmental Epigenetics Program, Thuwal, Saudi Arabia.ORCID 0000-0002-3178-0906
Steven E JacobsenDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9483-138X
John K KimDepartment of Biology, The Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-9838-3254

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Sexual dimorphism of piRNA transcription and target silencing mechanisms in C. elegansR01HD109667 · NICHD · JOHNS HOPKINS UNIVERSITY · PI John Kim · 2022 to 2026
$2.4M
Characterization of the function of gene body DNA methylationF32GM136115 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PICARD, COLETTE LAFONTAINE · 2020 to 2022
$201k
NICHD NIH HHS R01 HD109667NIGMS NIH HHS F32 GM136115NIGMS NIH HHS T32 GM144273NIH HHS P40 OD010440
6 · The paper itself

Abstract

The Argonaute CSR-1 is essential for germline development in

Indexed as

Adenosine TriphosphatasesCaenorhabditis elegansCaenorhabditis elegans ProteinsGerm CellsAnimalsChromatinFertilityGene Expression RegulationGene Expression Regulation, DevelopmentalHistonesMutationAdenosine TriphosphatasesCaenorhabditis elegans ProteinsChromatinCSR-1 protein, C elegansHistones

Identifiers

PMID40540580
PMCPMC12180489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.