Evidence map›Paper›PMID 40540558›Full record

ArticleScience advances2025

Instant and secure fixation of e-PTFE medical implants in surgery by designing a bioadhesive interface.

Yang Gao, Daming Liu, Jing Zhou, Wen Zhang, Danqi Sun, Shuyang Wang, Yipeng Yang, Yuchen Xiang, Yang Zhang, Wei Lei and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yang GaoState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.ORCID 0000-0001-5172-658X
Daming LiuDepartment of Orthopaedics, Tangdu Hospital, Xi'an, Shaanxi Province, China.
Jing ZhouState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.ORCID 0009-0009-3852-8824
Wen ZhangState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Danqi SunState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Shuyang WangState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Yipeng YangDepartment of Orthopaedics, Xijing Hospital, Xi'an, Shaanxi Province, China.
Yuchen XiangState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Yang ZhangDepartment of Orthopaedics, Xijing Hospital, Xi'an, Shaanxi Province, China.ORCID 0000-0001-8840-287X
Wei LeiDepartment of Orthopaedics, Xijing Hospital, Xi'an, Shaanxi Province, China.
Tongqing LuState Key Lab for Strength and Vibration of Mechanical Structures, Soft Machine Lab, School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.ORCID 0000-0002-1333-7978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expanded polytetrafluoroethylene (e-PTFE) is extensively used in medical implants for its excellent bioinertness. Existing methods to fix e-PTFE implants on host tissues mainly use invasive anchorage such as sutures, spiral tacks, or metal skeletons, which has limitations such as being time-consuming and causing leakage and tissue damage. To overcome these limitations, we introduce a bioadhesive interface to realize the adhering fixation of e-PTFE implants. We integrate a hydrophilic and bioadhesive hydrogel layer on the hydrophobic and bioinert e-PTFE by designing a facile approach of freezing-induced micromechanical interlocking. The integration is robust enough as pulling hydrogel out of the interlocked pores on e-PTFE requires large energy dissipation. This bioadhesive interface enables instant (operating time < 10 seconds) and secure (adhesion energy >200 joules per square meter) adhering fixation of e-PTFE implants to wet tissue. The advantages for reducing inflammatory response, fibrogenesis, and the resultant postoperative adhesion are further demonstrated in a reconstructive surgery of an abdominal wall defect in rabbits.

Indexed as

PolytetrafluoroethyleneProstheses and ImplantsAnimalsBiocompatible MaterialsHydrogelsRabbitsBiocompatible MaterialsHydrogelsPolytetrafluoroethylene

Identifiers

PMID40540558
PMCPMC12180491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.