ArticleScience advances2025
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
–field-weighted citation impact
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Who cites it
15 citing papers in PubMed.
- Urinary tract infections in children.Nature reviews. Urology · 2026Review
- Essential role for the urothelial plaque in Gram-negative urinary tract infections.Scientific reports · 2026Article
- Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection.PLoS pathogens · 2026Article
- The role of uropathogenicCurrent urology · 2026Review
- Study on drug resistance, biofilm formation, phylogenetic and virulence gene analysis of Escherichia coli from diarrheic lambs.BMC veterinary research · 2026Article
- Genomic and Pathogenic Characterization of an Extensively Drug-Resistant Avian PathogenicTransboundary and emerging diseases · 2026Article
- Comparative analysis of virulence and resistance gene profiles between carbapenem-resistant and ESBL-producingFrontiers in microbiology · 2026Article
- Chimeric vaccine based on Iraqi HLA alleles against a predominant localFrontiers in immunology · 2026Article
- An mRNA-based FimH nanoparticle vaccine against uropathogenicFrontiers in immunology · 2026Article
- Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference.Nature communications · 2025Article
- Protein-Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria.International journal of molecular sciences · 2025Review
- De Novo Design of Miniprotein Inhibitors of Bacterial Adhesins.Research square · 2025Article
- Uropathogenic Escherichia coli niche occupancy determines the effects of mucosal vaccine against FimH.Cell reports · 2025Article
- Article
Corrections and comments
- Update of
Authors and funding
17 authors.
Edward D B LopattoDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-6625-6143
Jesús M Santiago-BorgesDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-4710-3993
Denise A SanickDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-6903-0273
Sameer Kumar MalladiDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-5131-4518
Philippe N AzimzadehDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8172-5051
Morgan W TimmDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-2947-9508
Isabella F FoxDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Aaron J SchmitzDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-8077-6751
Jackson S TurnerDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-4396-6265
Shaza M Sayed AhmedDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Lillian OrtinauDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0009-0005-2783-1597
Nathaniel C GualbertoDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0009-0009-2697-5862
Jerome S PinknerDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-7389-7440
Karen W DodsonDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.
Ali H EllebedyDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-6129-2532
Andrew L KauDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-9386-3766
Scott J HultgrenDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8785-564X
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MRational design and synthesis of small molecule inhibitors targeting unique pathogenic mechanisms in Gram- and Gram+ bacteria important in UTIU19AI157797 · NIAID · WASHINGTON UNIVERSITY · PI ELLEBEDY, ALI HASSAN · 2021 to 2025
$11.4MCHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7MHarnessing Antibody Responses to Prevent and Treat Urinary Tract InfectionsR01AI165915 · NIAID · WASHINGTON UNIVERSITY · PI Andrew Leon Kau · 2022 to 2026
$3.1MPathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9MDoris Duke Charitable Foundation 2019083NIAID NIH HHS R01 AI029549NIAID NIH HHS R01 AI165915NIAID NIH HHS R37 AI048689NIAID NIH HHS U19 AI157797NIDDK NIH HHS P30 DK020579NIGMS NIH HHS T32 GM007067
Abstract
As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic
Indexed as
Adhesins, Escherichia coliAntibodies, MonoclonalEscherichia coli InfectionsFimbriae ProteinsUrinary Tract InfectionsUropathogenic Escherichia coliAnimalsFemaleHumansMiceAdhesins, Escherichia coliAntibodies, MonoclonalFimbriae ProteinsfimH protein, E coli
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.