SynthesisInternational journal of surgery (London, England)2025
Efficacy and safety of immunotherapy-based neoadjuvant regimens in locally advanced gastric cancer: a meta-analysis based on high-quality clinical trials.
Synthesis in International journal of surgery (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Addition of immunotherapy to perioperative chemotherapy for resectable gastric and gastroesophageal junction cancer: a meta-analysis of phase 2/3 trials.Frontiers in immunology · 2025Pooled it
- Article
- Finding a predictive index for evaluating the efficacy of neoadjuvant therapy in locally advanced gastric cancer patients.World journal of surgical oncology · 2026Article
- Distinct roles of nutritional and inflammatory signatures in predicting pathological response versus long-term survival in locally advanced gastric cancer treated with neoadjuvant immunotherapy.Frontiers in oncology · 2026Article
- Borrmann type IV gastric cancer exhibits distinct clinicopathological features and extremely poor prognosis.Frontiers in oncology · 2026Article
- Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe integration of chemotherapy, targeted therapy, and immunotherapy has emerged as the latest research focus for locally advanced gastric cancer (LAGC). This study aims to evaluate the efficacy and safety of various immunotherapy-based neoadjuvant regimens for LAGC.
methodsPubMed, EmBase, and Cochrane Library databases were systematically searched based on the predefined inclusion criteria. Subsequently, the Stata software (version 17) was employed to separately integrate the outcome indicators of the single- and dual-arm studies, thereby systematically assessing the antitumor effects of three distinct immunotherapy-based regimens: neoadjuvant immunotherapy plus chemotherapy (NICT), neoadjuvant chemotherapy plus targeted therapy (NCTT), and NICT plus targeted therapy (NICTT).
results16 high-quality Phase II prospective single-arm clinical studies and 7 dual-arm clinical studies were selected. The pooled results from the single-arm studies indicated that immune-based neoadjuvant therapy could increase the rates of pathological complete response (pCR), severe treatment-related adverse events (TRAEs), 1- and 3-year disease-free survival (DFS), as well as 1- and 3-year overall survival (OS) to 20%, 30%, 91%, 74%, 94%, and 81%, respectively. Pairwise meta-analysis indicated that both the NICT and NICTT groups achieved higher rates of pCR, major pathological response (MPR), and complete resection (R0 resection) compared to the neoadjuvant chemotherapy (NCT) group, with the NICTT group exhibiting more pronounced effects. The NICTT group exhibited a significantly higher risk of experiencing severe TRAEs compared to the NCT group. ICIs + XELOX appeared to be a more appropriate NICT regimen, as it effectively enhanced the tumor response rate while inducing less severe TRAEs. Tumors exhibiting positive expression of PD-L1 or microsatellite instable (MSI) demonstrated a higher level of responsiveness to the NICT regimen.
conclusionsImmunotherapy-based neoadjuvant regimens exhibit an enhanced potential for promoting tumor regression; however, caution is warranted due to the elevated risk of severe TRAEs.
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