Observational studyLiver international : official journal of the International Association for the Study of the Liver2025
Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant-Free Survival.
Observational study in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00518440 (A Multi-Center Trial to Study Acute Liver Failure in Adults), which is not on this map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-Center Trial to Study Acute Liver Failure in Adults
Who cites it
5 citing papers in PubMed.
- The role of systemic inflammation in hepatic encephalopathy: advances in inflammatory mechanisms, prevention and treatment research.Annals of medicine · 2026Review
- Role of viral and host factors in determining the outcome of HBV-associated acute liver failure.Journal of translational medicine · 2026Article
- Secondary hemophagocytic lymphohistiocytosis mimicking sepsis in hepatitis A-E coinfection: spontaneous recovery with supportive care.Archive of clinical cases · 2026Article
- Research Progress on the Mechanism and Targeted Intervention of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)-Mediated "Inflammation-Apoptosis-Metabolism-Microcirculation" Regulatory Network in Hepatitis B-Associated Liver Failure.Drug design, development and therapy · 2026Review
- Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant-Free Survival.Liver international : official journal of the International Association for the Study of the Liver · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
BACKGROUND &
aimsOnly 25% of hepatitis B-related acute liver failure (HBV-ALF) patients survive without liver transplantation (transplant-free survival, TFS). There is limited study of immunological and virological profiles in these patients. We analysed the association between hepatitis B viremia and cytokine patterns on TFS of HBV-ALF patients.
methodsWe identified 48 acute and 20 history of HBV infection ALF patients from the US ALF Study Group registry (> 3400 patients). The inclusion criteria were age > 18 years, diagnosis of HBV-ALF with hepatic encephalopathy and INR ≥ 1.5. Data were collected from ICU admission through day 21. Serum collected at admission and at days 3-5 were used for cytokine quantification by Luminex and novel HBV biomarkers, genotypes and variants.
resultsIn 48 acute (50% F, median age 40 years) and 20 history/reactivation (40% F, median age 53 years) HBV-ALF patients, there were 26 (54%) and 5 (25%) TFS, respectively. Detectable HBV DNA by clinical PCR assay (median 3.39 log
conclusionsAcute HBV-ALF patients with TFS were often viremic with immune escape variants, increased angiogenic factors and decreased pro-inflammatory cytokines.
trial registrationClinicalTrials.gov identifier: NCT00518440.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.