Evidence map›Paper›PMID 40540215›Full record

ArticleActa diabetologica2025

Should we treat mild gestational diabetes? An Australian multicentre retrospective cohort study.

Victoria L Rudland, Emily Hibbert, Jeff Flack, Tang Wong, Vincent W Wong, Mark McLean, Dharmintra Pasupathy, David Simmons, N Wah Cheung

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victoria L RudlandSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia. victoria.rudland@sydney.edu.au.ORCID http://orcid.org/0000-0002-6597-3060
Emily HibbertSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia.
Jeff FlackBankstown-Lidcombe Hospital, Sydney, Australia.
Tang WongBankstown-Lidcombe Hospital, Sydney, Australia.
Vincent W WongDepartment of Medicine, UNSW, Sydney, Australia.
Mark McLeanBlacktown Hospital, Sydney, Australia.
Dharmintra PasupathySydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia.
David SimmonsSchool of Medicine, Western Sydney University, Sydney, Australia.
N Wah CheungSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria for gestational diabetes (GDM) were widely implemented in Australia, despite limited evidence of better pregnancy outcomes compared to the Australasian Diabetes in Pregnancy Society 1998 (ADIPS1998) criteria. We aimed to evaluate the effect of treatment on pregnancy outcomes for women with 'mild' GDM, defined as GDM diagnosed by one, but not both, sets of criteria.

methodsThis multicentre, retrospective cohort study included 17,512 pregnant women in six neighbouring tertiary hospitals in Sydney, Australia, during 2016-2017, all of whom were screened for GDM using a three-point 75 g oral glucose tolerance test. Three hospitals diagnosed and treated GDM according to ADIPS1998 criteria, and three according to IADPSG criteria. For women with 'mild' GDM, we evaluated the effect of treatment versus no treatment on pregnancy outcomes. The primary outcome was large for gestational age. Secondary outcomes were small for gestational age, induction of labour, caesarean section, gestational hypertension, and preeclampsia.

results2320 (13.2%) pregnant women had 'mild' GDM. Treatment of women with IADPSG-only GDM (i.e. fasting glucose 5.1-5.4 mmol/L (91-97 mg/dL) and/or 1-hour glucose ≥ 10.0 mmol/L (≥ 180 mg/dL)) was associated with less large for gestational age infants than no treatment (RR 0.66, 95%CI 0.49-0.88, p = 0.004) but more induction of labour (RR 1.55, 95%CI 1.03-2.34, p = 0.032). Treatment of women with ADIPS1998-only GDM (i.e. 2-hour glucose 8.0-8.4 mmol/L (144-151 mg/dL)) did not significantly change pregnancy outcomes compared with no treatment.

conclusionsThis study highlights the importance of treating even mild IADPSG-GDM to improve pregnancy outcomes.

Indexed as

Diabetes, GestationalAdultAustraliaBlood GlucoseFemaleGlucose Tolerance TestHumansPregnancyPregnancy OutcomeRetrospective StudiesBlood GlucoseDiabetesGestationalGlucose tolerance testMild gestational diabetesPregnancyPregnancy outcome

Identifiers

PMID40540215
PMCPMC12727755

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