Evidence map›Paper›PMID 40540211›Full record

ArticleActa diabetologica2025

The association of peripheral blood METTL3 mRNA expression levels with prediabetes and type 2 diabetes mellitus: the Henan rural cohort study.

Yujie Jiang, Xiaoying Ren, Yuqian Li, Gaohua Chang, Xintao Pan, Yahui Zhang, Chongjian Wang, Xiaotian Liu

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Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Yujie JiangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China.
Xiaoying RenDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China.
Yuqian LiDepartment of Clinical Pharmacy, School of Pharmacy, Zhengzhou University, Zhengzhou, 450001, Henan, PR China.
Gaohua ChangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China.
Xintao PanDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China.
Yahui ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China.
Chongjian WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. tjwcj2005@126.com.
Xiaotian LiuDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. xtliu2008@126.com.ORCID http://orcid.org/0000-0002-5426-9158

Funding

China Postdoctoral Science Foundation 2020M672297Chinese Nutrition Society-Danone Dietary Nutrition Research and Education Fund DIC2020-04Key Research Program of Colleges and Universities in Henan Province 21A330007National Key Program of Research and Development of China 2016YFC0900803National Natural Science Foundation of China 42177415National Natural Science Foundation of China 82003543Science and Technique Foundation of Henan Province 232102311129Science and Technology Innovation Team Support Plan of Colleges and Universities in Henan Province 21IRTSTHN029Yum China Dietary Health Foundation CNS-YUM2020A19
6 · The paper itself

Abstract

aimWe aimed to investigate the association of peripheral blood METTL3 (Methyltransferase Like 3) mRNA expression levels with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). MATERIALS AND

methodsA case-control study including 1501 participants from the Henan Rural Cohort study was performed. Peripheral blood METTL3 mRNA expression levels were quantified by qRT-PCR. Binary logistic regression was used to generate odds ratio (OR) and 95% confidence intervals (CI) for the risk of IFG and T2DM. Restricted cubic spline was used to generate the dose-response relationship between METTL3 mRNA expression levels and IFG and T2DM.

resultsMETTL3 mRNA expression levels were downregulated in T2DM compared with normal glucose tolerance (NGT) (4.03 ± 1.09 vs. 3.96 ± 0.93). After adjusting covariates, the risk of developing IFG in METTL3 mRNA high expression levels group was 30% higher than that in the low expression levels group (OR = 1.30,95%CI:1.02,1.65). Conversely, METTL3 mRNA expression levels were negatively correlated with T2DM(OR = 0.83,95%CI:0.72,0.96) compared to the NGT group. METTL3 mRNA expression levels showed a non-linear correlation with both IFG and T2DM.

conclusionMETTL3 mRNA expression levels exhibited opposing effects on IFG and T2DM. Elevated METTL3 mRNA levels were positively associated with IFG risk but inversely associated with T2DM risk.

Indexed as

Diabetes Mellitus, Type 2MethyltransferasesPrediabetic StateRNA, MessengerAdultAgedBlood GlucoseCase-Control StudiesChinaCohort StudiesFemaleHumansMaleMiddle AgedRural PopulationBlood GlucoseMethyltransferasesMETTL3 protein, humanRNA, MessengerCase-control studyHenan rural cohort studyImpaired fasting glucoseMETTL3 mRNA expression levelsType 2 diabetes mellitus

Identifiers

PMID40540211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.