Evidence map›Paper›PMID 40540176›Full record

ArticleMolecular neurobiology2025

The Antinociceptive Effect of Nicorandil in Neuropathic and Nociceptive Pain is Partially Mediated via TRPV1/Opioidergic Signaling.

Rasha M Badr, Salwa A Abuiessa, Samar S Elblehi, Nayera W Hassan, Elham A Afify

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rasha M BadrDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Alexandria, 1-El-Khartoum Square, Azarita, Alexandria, Postal Code: 21521, Egypt.
Salwa A AbuiessaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Alexandria, 1-El-Khartoum Square, Azarita, Alexandria, Postal Code: 21521, Egypt.
Samar S ElblehiDepartment of Pathology, Faculty of Veterinary Medicine, University of Alexandria, Alexandria, Egypt.
Nayera W HassanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
Elham A AfifyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Alexandria, 1-El-Khartoum Square, Azarita, Alexandria, Postal Code: 21521, Egypt. elham.afifi@alexu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropathic pain is a serious neurological disorder caused by lesioned somatosensory neurons characterized by multiple pathologies. Transient receptor potential vanilloid 1 (TRPV1) channels and opioid receptors are co-expressed in dorsal root ganglia (DRG) and play a crucial role in the development of neuropathic pain. Here, we investigated the possible involvement of TRPV1 channels and µ-opioid receptors in mediating the antinociception of the K

Indexed as

AnalgesicsNeuralgiaNicorandilNociceptive PainSignal TransductionTRPV Cation ChannelsAnimalsCapsaicinGanglia, SpinalMaleRatsRats, Sprague-DawleyRats, WistarAnalgesicsCapsaicinNicorandilTrpv1 protein, ratTRPV Cation ChannelsNeuropathic painNicorandilOpioidergicTRPV1

Identifiers

PMID40540176
PMCPMC12433447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.