Evidence map›Paper›PMID 40540111›Full record

ReviewInflammopharmacology2025

Optimizing wound healing: insights from phytochemicals and advanced therapies.

Adwitiya Mitra, Ayesha Shahid, Shivangi Kumari, Tuhin Mukherjee, Shiladitya Pramanick, Satyajit Mohanty, Mohammad Azam Ansari, Krishnendu Adhikary, Pranav Kumar Prabhakar, Kavindra Kumar Kesari

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Frontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adwitiya Mitra *Clinical Research Group, Torrent Pharmaceuticals Ltd, Gandhinagar, Gujarat, 382428, India.
Ayesha Shahid *Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Shivangi KumariDivision of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Tuhin MukherjeeDivision of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India. tuhin.bzs@gmail.com.ORCID http://orcid.org/0000-0002-8114-9952
Shiladitya PramanickDivision of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Satyajit MohantyDivision of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India. satyajitmohanty922@gmail.com.ORCID http://orcid.org/0000-0001-6665-3432
Mohammad Azam AnsariDepartment of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia.
Krishnendu AdhikaryDepartment of Interdisciplinary Science, Centurion University of Technology and Management, R.sitappur, Odisha, 761211, India.
Pranav Kumar PrabhakarResearch and Development, Parul University, Post Limda, Waghodia, Gujarat, 391760, India.
Kavindra Kumar KesariDepartment of Applied Physics, School of Science, Aalto University, 00076, Espoo, Finland. kavindra.kesari@aalto.fi.ORCID http://orcid.org/0000-0003-3622-9555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a complex process with various dimensions, often presenting as a growing concern that prompts the quest for advancements. This review emphasizes the therapeutic potential of medicinal plants rich in flavonoids, terpenoids, polyphenols, alkaloids, and steroids and discusses their valuable antibacterial, antioxidant, and anti-inflammatory properties in wound management. Cross talk of the phytochemicals with the intricate phases of wound healing, encompassing hemostasis, inflammation, proliferation, and remodeling is detailed, highlighting essential cellular and molecular mechanisms crucial for effective tissue repair. Chronic wounds, a significant global health concern, underscore the importance of advancing wound care therapies. Various treatment modalities, from platelet-rich plasma (PRP) and stem cell therapy to gene therapy, offer diverse mechanisms to promote wound closure and tissue regeneration and mitigate infection risk. Challenges such as variable efficacy, cost, and limited availability necessitate ongoing research for optimal wound management strategies. Wound dressings play a pivotal role in wound care by providing protective barriers against microbial invasion, facilitating tissue regeneration, and maintaining a moist wound environment conducive to healing. The review outlines various types of dressings, including hydrocolloid, foam, alginate, hydrogel, collagen, silver, transparent film, and composite dressings, each offering specific functions and limitations. Appropriate dressing selection depends on wound type, exudate level, and desired therapeutic outcomes. This review offers valuable insights into the complex landscape of wound-healing research and treatment. Synthesizing recent advancements in natural compounds, therapeutic interventions, and wound dressing technologies provides a comprehensive overview of current understanding and future directions in wound care.

Indexed as

PhytochemicalsWound HealingAnimalsAnti-Inflammatory AgentsBandagesHumansPlants, MedicinalAnti-Inflammatory AgentsPhytochemicalsAlkaloidsFlavonoidsMedicinal plantsPhytochemicalsPolyphenolsSteroidsTherapeutic approachesWound healing

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.