Observational studyInternational ophthalmology2025
Dry eye after photorefractive keratectomy (PRK) and transepithelial photorefractive keratectomy (T-PRK): a comparative clinical study.
Observational study in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Clinical outcomes and safety of preservative-free diclofenac sodium eye drops in SPT-assisted transepithelial photorefractive keratectomy.Frontiers in pharmacology · 2026Article
- Perioperative low-level light therapy for ocular surface protection in patients undergoing Femto-LASIK: a prospective double-masked, randomized controlled study.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare dry eye disease (DED) following PRK and T-PRK surgeries using a combined approach of subjective and objective measures, focusing on clinically meaningful outcomes and adjusted statistical modeling.
methodsIn this prospective observational study, 89 eyes of patients aged over 20 years were enrolled and grouped into PRK (43 eyes) and T-PRK (46 eyes). The primary outcome was change in ocular surface diseases index (OSDI) score at 6 months. Secondary outcomes included non-invasive tear breakup time (NITBUT) and meibomian gland expressibility. Exploratory parameters such as tear meniscus height (TMH), redness score, strip meniscometry (SM Tube), meibomian gland dropout, and meibum quality were also assessed. Statistical models were adjusted for baseline age differences, and corrections for multiple comparisons were applied.
resultsThe mean age of the patients was 34.16 ± 7.23 in the PRK and 28.72 ± 6.26 in the T-PRK group (P < 0.001). The two groups were not significantly different for gender (P = 0.367). After statistical adjustment, only the change in OSDI and NITBUT at 1-month remained significant between groups (adjusted P = 0.038 and P < 0.05, respectively). Effect sizes were small to moderate, and none of the differences exceeded minimal clinically important thresholds. Exploratory analyses revealed no significant between-groups differences. Age was identified as an independent predictor of OSDI change.
conclusionIn short-term follow-up, both procedures induced some degree of DED. However, T-PRK was associated with slightly fewer signs and symptoms of dry eye disease, but the differences were not clinically significant.
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Registered trials
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