Evidence map›Paper›PMID 40540098›Full record

SynthesisNeurosurgical review2025

The role of neuroendoscopy in treatment of pediatric brain abscesses: case series and systematic review of the literature.

Piero Spennato, Francesco Tengattini, Stefania Picariello, Linda Gritti, Massimiliano Porzio, Claudio Ruggiero, Giulia Meccariello, Giuseppe Cinalli

Abstract readSystematic ReviewCase Reports
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Piero Spennato *Neurosurgery Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital AORN, Naples, Italy.
Francesco Tengattini *Neurosurgery Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital AORN, Naples, Italy. f.tengattini003@unibs.it.
Stefania PicarielloNeuro-Oncology Unit, Department of Paediatric Oncology, Santobono-Pausilipon Children's Hospital AORN, Naples, Italy.
Linda GrittiDivision of Neurosurgery, Department of Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Massimiliano PorzioUnit of Neurosurgery, Department of Biomedicine, Neuroscience and Advanced Diagnostics, Post Graduate Residency Program in Neurosurgery, University of Palermo, Palermo, Italy.
Claudio RuggieroNeurosurgery Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital AORN, Naples, Italy.
Giulia MeccarielloNeurosurgery Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital AORN, Naples, Italy.
Giuseppe CinalliNeurosurgery Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital AORN, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of brain abscesses in children requires a multimodal approach, consisting of neurosurgical evacuation and intravenous antibiotics. Endoscopic aspiration has been used for extensive removal of the purulent collection, but few pediatric cases have been described in literature. We report the management of endoscopically treated brain abscesses in children in our department and provide a systematic review of the literature. We retrospectively collected data on a series of children with intracerebral abscesses treated endoscopically. The literature search was performed and studies between 1979 and 2024 were included. Seven cases were retrieved, 3 were neonates and 4 were 6–14 years old. Neuronavigationwas used to plan the access point and trajectory. The endoscopic approach under a direct vision with the use of an endoscopic ultrasonic aspirator was chosen to ensure the maximum safe resection and thus reduce the possibility of recurrence. All patients were also treated with intravenous antibiotics. Surgeries were uneventful and without recurrence. Six papers (9 patients) reporting endoscopic evacuation of intracranial abscesses were identified in the literature. The age of the patients ranged between 4 months and 11 years. In none of the cases described the ultrasonic aspirator was used for abscess drainage. Endoscopic aspiration is an effective method for treatment of intracranial abscesses in children. Neuronavigation is highly recommended to identify the optimal entry point, especially for deep-seated lesions. The ultrasonic aspirator plays a key role in efficiently removing the collections. This method is particularly important for children, where minimizing invasiveness is crucial. Further studies are needed to identify the optimal duration of the intravenous antibiotic treatment after neuroendoscopic surgery, whether it can be shorter than that of the standard intervention.

Indexed as

Brain AbscessNeuroendoscopyAdolescentAnti-Bacterial AgentsChildChild, PreschoolDrainageFemaleHumansInfantInfant, NewbornMaleNeuronavigationTreatment OutcomeAnti-Bacterial AgentsBrain abscessNeuroendoscopyPediatricUltrasonic aspirator

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.