Observational studyInternational ophthalmology2025
A novel metric to monitor early progression in keratoconus: epithelial backscatter.
Observational study in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Influence of Scleral Contact Lenses on Optical Coherence Tomography Parameters in Keratoconus Patients.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the keratoconus progression over the course of one-year using epithelial and anterior stromal backscatter, Belin ABCD progression display, and various Pentacam
methodsThis single-centre, retrospective, longitudinal, observational study evaluated change in epithelial and anterior stromal backscatter (using the line densitometry feature of the Pentacam
resultsWhen compared to the baseline after one-year, epithelial backscatter increased (p < 0.05); posterior radius of curvature, BAD-D, average PPI, index of vertical asymmetry (IVA), and index of height decentration (IHD) worsened (p < 0.05); and the anterior stromal backscatter, keratometry values, Belin ABCD stages, thinnest pachymetry, elevations, and ARTmax remained stable (p > 0.05). There were statistically significant weak-to-moderate correlations between the backscatter values and Pentacam
conclusionEpithelial backscatter can be considered a novel parameter to monitor the progression of keratoconus, as it was found to have similar abilities to those of the posterior radius of curvature, BAD-D, average PPI, IVA, and IHD, all of which demonstrated early evolution during one-year of follow-up, while the front keratometric data exhibited no progression. Moreover, by generalizing single-point backscatter data to the entire corneal surface, epithelial backscatter can be integrated into Pentacam
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