Evidence map›Paper›PMID 40540009›Full record

ReviewUrologie (Heidelberg, Germany)2025

Metabolic evaluation of urolithiasis: a narrative review.

Panagiotis Angelopoulos, Panagiotis Neofytoy, Stamatios Katsimperis, Panagiotis Triantafylloy, Ioannis Manolitsis, Michael Lardas, Titos Markopoulos, Ioannis Varkarakis, Lazaros Tzelves, Andreas Skolarikos

Abstract readReview
In one paragraph

Review in Urologie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Panagiotis AngelopoulosSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece. angelopoulospanag@gmail.com.
Panagiotis NeofytoySecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Stamatios KatsimperisSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Panagiotis TriantafylloySecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Ioannis ManolitsisSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Michael LardasSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Titos MarkopoulosSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Ioannis VarkarakisSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Lazaros TzelvesSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.
Andreas SkolarikosSecond Department of Urology, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urolithiasis is a common condition with high recurrence rates, often driven by metabolic abnormalities, dietary habits, and systemic disorders. Metabolic evaluation plays a key role in identifying modifiable risk factors such as hypercalciuria, hyperoxaluria, hypocitraturia, and hyperuricosuria. Despite its clinical value, metabolic evaluation remains underused in practice. This narrative review highlights the rationale, methods, and therapeutic implications of metabolic assessment in patients with recurrent or high-risk stone disease. The evaluation includes medical and dietary history, physical examination, blood and urine tests, 24‑h urine collections, and stone analysis. Tailored interventions-ranging from dietary advice to pharmacologic treatments such as thiazides, potassium citrate, and allopurinol-can reduce stone recurrence and prevent complications such as chronic kidney disease. Ongoing follow-up is essential to assess treatment response and modify strategies. Adherence to current guidelines and broader implementation of metabolic workup can significantly improve patient outcomes and reduce the global burden of stone disease.

Indexed as

UrolithiasisHumansEndourologyFollow-upKidney stonesMetabolic evaluationUrolithiasis

Identifiers

PMID40540009
PMCPMC12202690

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.