Evidence map›Paper›PMID 40539934›Full record

ArticleJournal of psychopharmacology (Oxford, England)2025

Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABA

Jaren A Reeves-Darby, Lais F Berro, Heather L Hembree, James P Shaffery, James K Rowlett, Dishary Sharmin, Prithu Mondal, James M Cook, Donna M Platt

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jaren A Reeves-DarbyDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Lais F BerroDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Heather L HembreeDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
James P ShafferyDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
James K RowlettDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-4077-5017
Dishary SharminDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Prithu MondalDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Donna M PlattDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-8369-9544

Funding

ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDSR01DA011792 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 1998 to 2024
$7.8M
Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentR01DA043204 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI JAMES K ROWLETT · 2017 to 2026
$4.3M
GABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
Role of orexin receptors in the abuse- and sleep-related effects of methamphetamineR00DA049886 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI BERRO, LAIS F · 2022 to 2024
$747k
Alcohol-induced decreases in REM sleep: GABA-A receptor subtypesF31AA029306 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI REEVES-DARBY, JAREN ASHER · 2021 to 2023
$140k
NIAAA NIH HHS F31 AA029306NIAAA NIH HHS R01 AA029023NIDA NIH HHS R00 DA049886NIDA NIH HHS R01 DA011792NIDA NIH HHS R01 DA043204NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

backgroundAlcohol use disorder patients experience reductions in rapid eye movement (REM) sleep and other sleep problems. Little is known about the pharmacological mechanism(s) involved in this effect.

aimsThis study compared sleep-wake states and electroencephalography (EEG) spectral power following exposure to ethanol and GABA

methodsSprague-Dawley rats received ethanol or subtype-selective GABA

resultsSleep-wake state analysis demonstrated that ethanol, the nonselective compound alprazolam, the α1-selective compound zolpidem, the α2/3-selective compound KRM-II-81, and the α5-selective compound MP-III-022 produced decreases in REM sleep. By contrast, the α4/6-selective compound, gaboxadol, only increased time spent in slow-wave sleep (SWS). KRM-II-81 was the only compound to produce increases in time spent awake. The EEG spectral power analysis revealed that all compounds produced a unique signature, but none produced a signature similar to ethanol.

conclusionsAnalysis of sleep-wake states after administration of ethanol or GABA

Indexed as

EthanolGABA-A Receptor AgonistsReceptors, GABA-ASleep, REMAlprazolamAnimalsElectroencephalographyElectromyographyIsoxazolesMalePyridinesRatsRats, Sprague-DawleyWakefulnessZolpidemAlprazolamEthanolGABA-A Receptor AgonistsgaboxadolIsoxazolesPyridinesReceptors, GABA-AZolpidemEEG/EMG recordingEthanolGABAA receptorssleep architecturespectral power

Identifiers

PMID40539934
PMCPMC12935073

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.