ArticleInternational journal of radiation biology2025
Exploring Auger electron-emitting radionuclides for targeted DNA damage in mismatch repair-deficient cells: a theoretical study of
Article in International journal of radiation biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Monte Carlo-based subcellular comparison of electron energy deposition byEJNMMI physics · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
purposePreserving the integrity of the genome is critical to healthy cellular growth and development. Under normal circumstances, the eukaryotic mismatch repair (MMR) machinery is effective at detecting DNA polymerase errors and maintaining the fidelity of the genome. However, cells with inactivated MMR machinery are prone to the accumulation of mutations and tumorigenesis. This study explores the theoretical potential of rhodium-99- and iodine-123-labeled DNA metalloinsertors as Auger electron-emitting radiotherapeutics for cancers characterized by MMR deficiency. MATERIALS AND
methodsA Monte Carlo code was developed in MATLAB
resultsDifferences in the Auger electron emission spectra of
conclusionThis theoretical study leverages both simulation and comparative analyses to identify
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Registered trials
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