ArticleActa paediatrica (Oslo, Norway : 1992)2025
Testing for Faecal Gluten Immunogenic Peptides: Is It Useful to Evaluate Adherence to Gluten-Free Diet?
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimDetermination of faecal gluten immunogenic peptides (f-GIP) has recently been proposed as new noninvasive method to detect gluten intake in celiac disease (CD). Our aim was to evaluate the use of f-GIP for the adherence to gluten-free diet (GFD) and to compare this new marker with traditional methods.
methodsWe enrolled both newly diagnosed cases and children in follow-up with CD. Adherence to the GFD was assessed using the Biagi score, IgA anti-transglutaminase (tTG IgA) and f-GIP.
resultsSeventy-one CD children, 40.8% new diagnosis and 59.2% in follow-up, were enrolled. Significant differences were found in the levels of faecal GIP between new diagnosis and follow up (median 185.7 ng/mL, IQR 67.8-318.8 ng/mL and 16.6 ng/mL, IQR 6.9-61 ng/mL respectively, p < 0.001). A significant direct correlation was found between faecal GIP and tTG IgA in the total cohort of enrolled patients (r = 0.5, p < 0.001). In the follow up group, 21.4% tested positive for GIP and, of these GIP + patients, 78% had a high Biagi score.
conclusionOur data shows that faecal GIP offers a precise assessment of even occasional exposure to gluten and suggests it might represent a less invasive instrument to check dietary adherence compared to traditional methods.
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