SynthesisAnnals of medicine2025
Association between circulating irisin level and depression: a systematic review and meta-analysis.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gene-Physical Activity Interplay in Depression: Candidate-Gene Interactions, Polygenic Susceptibility, Lifestyle Context, and Mendelian Randomization Evidence-Systematic Review.Journal of clinical medicine · 2026Review
- Comparative psychological well-being evaluation among CKD patients on conservative therapy, dialysis, or kidney transplantation: a cross-sectional study.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have presented controversial results about the association between irisin and depression. This research is designed to explore the circulating irisin levels in depressive patients.
methodsFrom the earliest available records up to 18 July 2024, searches were conducted in databases of PubMed, Embase, Web of Science, the Cochrane Library, and Scopus, in order to identify the relevant articles assessing the correlation between irisin and depression in humans. Two reviewers screened reports, retrieved and collected data independently.
resultsTotally, eight articles with 2044 samples (733 depressive patients and 1311 non-depressive individuals) were involved. The results indicated lower circulating irisin levels in depression (standardized mean difference [SMD] = 0.60, 95% confidence interval [CI]: 0.08 to 1.12,
conclusionsThe results of this research demonstrated that irisin levels were decreased in depressive patients, and there was a negative correlation between irisin levels and depressive scores, indicating that the lower the circulating irisin level, the more severe the depressive symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.