Trial reportEarly intervention in psychiatry2025
Descriptive Characteristics of Psychiatric Medication Discontinuation Among Perinatal Women With Depressive Symptoms.
Trial report in Early intervention in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02760004 (PRogram In Support of Moms), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRogram In Support of Moms: An Innovative Stepped-Care Approach for Obstetrics and Gynecology Clinics
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Authors and funding
9 authors.
Funding
Abstract
introductionThis study examined the prevalence of psychiatric medication discontinuation amongst perinatal women with depressive symptoms and describes characteristics of those who discontinued compared to those who continued medications in pregnancy.
methodsWe conducted a cross-sectional analysis using baseline data from the PRogram In Support of Moms study. Amongst 98 women prescribed psychiatric medication, we descriptively assessed sociodemographic characteristics of participants who discontinued versus continued medications. A logistic regression model evaluated the association between depressive symptoms and medication discontinuation.
resultsApproximately 65% reported medication discontinuation in pregnancy (95% CI: 55%-74%). Those who discontinued had a median Edinburgh Postnatal Depression Scale (EPDS) score that was 1 point higher than those who continued (p = 0.12). Of those who discontinued medications, 27% were never married, 52% reported annual incomes < $60 000, and 56% were Medicaid-insured.
conclusionMost participants prescribed psychiatric medications before pregnancy discontinued them in pregnancy. Adequately powered studies are needed to validate findings and to explore mediating factors.
trial registrationNCT02760004.
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