ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Brachyury-Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global trends and hotspots of macrophage-related research in intervertebral disc degeneration from 2005 to 2025: a bibliometric and visualized analysis.Frontiers in immunology · 2026Pooled it
- MnOMaterials today. Bio · 2026Article
- Bioactive hydrogels for bone tissue engineering: Design strategies, bioactive cargo delivery, and artificial intelligence-assisted clinical translation.Asian journal of pharmaceutical sciences · 2026Review
- A nature-derived, strong adhesive hydrogel microsphere for wet tissue repair: Multifunctional and clinical potential.Bioactive materials · 2026Article
- Ultrasound-responsive CPS piezoelectric hydrogel synergistically repairs annulus fibrosus defects through immune reprogramming and cell recruitment.Materials today. Bio · 2026Article
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- Fucoidan and alginate from brown seaweeds: extraction, structural diversity, biocompatibility, biodegradability, and biomedical applications.Frontiers in plant science · 2026Review
- Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives.Research (Washington, D.C.) · 2026Review
- Cuttlefish ink nanoparticle-engineered hydrogel microspheres synergistically attenuate disc degeneration via antioxidant defense and matrix synthesis activation.Materials today. Bio · 2025Article
- Brachyury-Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Extracellular matrix (ECM) metabolic disorders and the establishment of inflammatory microenvironment are the primary pathological alterations associated with intervertebral disc degeneration (IVDD). The inflammatory microenvironment promotes ECM degradation, further exacerbating the vicious cycle of nucleus pulposus (NP) degeneration. This study introduces the mRNA encoding a novel therapeutic transcription factor, Brachyury (Bry), into nucleus pulposus cells (NPCs) using an injectable microsphere system composed of biomimetic GelMA/Fucoidan (FU) dual-component hydrogel (GF) and surface chemically grafted lipid nanoparticles (LNP) (BLNP@GF). The study aims to alleviate inflammatory response in the NP while restoring the ECM secretion function of NPCs and enhancing the ability of NPCs to withstand inflammatory stress, thereby restoring physiological balance in the NP microenvironment. The GF microspheres demonstrate injectability and porosity, facilitating efficient LNP loading through chemical grafting. In the LPS-simulated inflammatory microenvironment, sustained release of FU significantly reduces inflammatory activity in NPCs. Successful transfection with Bry mRNA upregulate ECM synthesis in degenerated NPCs. In a rat tail puncture IVDD model, local application of BLNP@GF microspheres effectively improved ECM remodeling in NP tissue, thereby ameliorating puncture-induced IVDD. In conclusion, FU-functionalized GelMA hydrogel microspheres loaded with Bry mRNA provide a promising new strategy for reversing IVDD.
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Registered trials
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